2-(morpholin-4-yl)-1,3-thiazol-4-ol | 19983-32-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(morpholin-4-yl)-1,3-thiazol-4-ol
• 英文别名: 4-hydroxy-2-morpholino-thiazole；2-morpholin-4-yl-thiazol-4-one；2-Morpholino-4-hydroxy-thiazol；2-Morpholino-4-hydroxythiazol；2-(4-Morpholinyl)-1,3-thiazol-4-ol；2-morpholin-4-yl-1,3-thiazol-4-ol
• CAS: 19983-32-5
• 化学式: C₇H₁₀N₂O₂S
• 分子量: 186.235
• InChiKey: PDPNDTMAECQGCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  73.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(morpholin-4-yl)-1,3-thiazol-4-ol 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 反应 1.0h， 以44%的产率得到4-氯-2-(4-吗啉)-5-噻唑甲醛
  参考文献：
  名称：

  Darstellung und Charakterisierung N-Disubstituierter 2-Amino-4-chlor-thiazol-5-aldehyde und ihrer Dicyanmethylen-Derivate

  摘要：

  In contrast to N-disubstituted 3-hydroxy-anilines 5 which react with the Vilsmeier reagent to N-substituted 4-amino-salicylaldehydes 7 their heteroanalogous N-disubstituted 2-amino 4-hydroxy-thiazoles 6 react with the same reagent to N-substituted 2-amino-4-chloro-thiazole-5-aldehydes 12 via their corresponding iminium salts precursors 11. Both types of compounds can be transformed, in analogy to other 2-amino-thiazole-5-aldehydes, by reaction with malodinitrile 13 into stable N-substituted 2-amino-4-chloro-5-(2,2-dicyano-ethenyl)-thiazoles 14.

  DOI：

  10.1002/prac.19963380108

文献信息

• Synthesis, Characterization, and Antibacterial Activity of Novel (1H-Benzo[d]imidazole-2-yl)-6-(diethylamino)-3H-one-xanthene, Phenoxazine, and Oxazine
  作者：Vikas S. Patil、Vikas S. Padalkar、Kiran R. Phatangare、Prashant G. Umape、Bhushan N. Borase、N. Sekar

  DOI：10.1002/jhet.1998

  日期：2015.1

  A series of novel (1H‐benzo[d]imidazole‐2‐yl)‐6‐(diethylamino)‐3H‐one‐xanthene, phenoxazine, and oxazine derivatives have been synthesized from 2‐(2′,4′‐dihydroxyphenyl) benzimidazole intermediate. Synthesized compounds 8a, 8b, 8c, 8d are fluorescent in solution, photophysical properties of compounds were studied and results revealed that compounds absorb and emit in UV–visible region with good fluorescence

  从2-（2'，4'-二羟基苯基）合成了一系列新颖的（1H-苯并[d]咪唑-2-基）-6（二乙氨基）-3H-蒽吨，苯恶嗪和恶嗪衍生物苯并咪唑中间体。合成的化合物8a，8b，8c，8d在溶液中发荧光，研究了化合物的光物理性质，结果表明化合物在紫外可见光区域吸收和发射，具有良好的荧光量子产率。合成的化合物在高达300°C的温度下具有热稳定性。通过很好的扩散方法研究了合成化合物的抗菌活性。大肠杆菌（ATTC‐25922），金黄色葡萄球菌（ATCC‐25923），微球菌s（ATCC‐4698）和枯草芽孢杆菌（ATCC‐55422）用于研究抗菌活性。
• OPTICAL FILTER
  申请人：Kyowa Hakko Chemical Co., Ltd.

  公开号：EP1813651A1

  公开（公告）日：2007-08-01

  The present invention provides optical filters comprising a squarylium compound represented by General Formula (I): [wherein R1 and R2 may be the same or different and each represents a hydrogen atom, an alkyl group optionally having substituent(s) or the like, R3 represents a hydrogen atom or an alkyl group optionally having substituent(s), and Y represents a group represented by General Formula (A): (wherein R4 represents a hydrogen atom, an alkyl group optionally having substituent(s) or the like, R5 represents a hydrogen atom, a halogen atom or the like, and R6, R7, R8 and R9 may be the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group optionally having substituent(s) or the like)] and the like.

  本发明提供了由通式 (I) 所代表的鳞片状化合物组成的滤光片： [其中 R1 和 R2 可以相同或不同，各自代表氢原子、可选具有取代基的烷基或类似物，R3 代表氢原子或可选具有取代基的烷基，Y 代表通式（A）所代表的基团： (其中 R4 代表氢原子、任选具有取代基的烷基或类似基团，R5 代表氢原子、卤素原子或类似基团，R6、R7、R8 和 R9 可以相同或不同，且各自代表氢原子、卤素原子、任选具有取代基的烷基或类似基团）]等。
• Darstellung und Charakterisierung N-Disubstituierter 2-Amino-4-chlor-thiazol-5-aldehyde und ihrer Dicyanmethylen-Derivate
  作者：Jens Erhard Israel、Ronald Flaig、Horst Hartmann

  DOI：10.1002/prac.19963380108

  日期：——

  In contrast to N-disubstituted 3-hydroxy-anilines 5 which react with the Vilsmeier reagent to N-substituted 4-amino-salicylaldehydes 7 their heteroanalogous N-disubstituted 2-amino 4-hydroxy-thiazoles 6 react with the same reagent to N-substituted 2-amino-4-chloro-thiazole-5-aldehydes 12 via their corresponding iminium salts precursors 11. Both types of compounds can be transformed, in analogy to other 2-amino-thiazole-5-aldehydes, by reaction with malodinitrile 13 into stable N-substituted 2-amino-4-chloro-5-(2,2-dicyano-ethenyl)-thiazoles 14.