(+/-)-2,3-diphenyltartratic acid | 74543-90-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (+/-)-2,3-diphenyltartratic acid
• 英文别名: meso-2,3-diphenyltartratic acid；diphenyltartaric acid；Diphenylweinsaeure；2,3-dihydroxy-2,3-diphenylbutanedioic acid
• CAS: 74543-90-1
• 化学式: C₁₆H₁₄O₆
• 分子量: 302.284
• InChiKey: KUDFYMVTRILOHI-UHFFFAOYSA-N

物化性质

• 熔点：
  115 °C
• 沸点：
  463.0±45.0 °C(Predicted)
• 密度：
  1.496±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  苯甲酰甲酸 在 vanadium(II) perchlorate 作用下， 以 水 为溶剂， 生成 (+/-)-2,3-diphenyltartratic acid
  参考文献：
  名称：

  Reduction of .alpha.-keto acids by low-valent metal ions. 2. Reaction of aqueous vanadous ion with pyruvic and phenylglyoxylic acids

  摘要：

  DOI：

  10.1021/ja00529a028

文献信息

• [EN] PROCESSES FOR PREPARING 4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6- DIHYDRO [L,2,41-TRIAZOLO[43-A]PYRAZIN-7(8H)-YL]-L-(2,4,5- TRIFLUOROPHENYL)BUTAN-2-AMINE<br/>[FR] PROCÉDÉS DE PRÉPARATION DE 4-OXO-4-[3-(TRIFLUOROMÉTHYL)-5,6-DIHYDRO- [L,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHÉNYL)- BUTAN-2-AMINE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2013065066A1

  公开（公告）日：2013-05-10

  The present invention relates to synthesis of 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2- amine of Formula (I) either in its racemic (R/S) form or any of its optically active (S) or (R) forms or enantiomeric excess mixture of any of the forms by novel processes. The invention further relates to certain novel intermediates useful in the preparation of compound of Formula (I) and processes for their preparation.

  本发明涉及通过新颖的方法合成式(I)的4-氧代-4-[3-(三氟甲基)-5,6-二氢[1,2,4]-三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-胺，其可以是其消旋（R/S）形式或其任何光学活性（S）或（R）形式或任何形式的对映过量混合物。该发明还涉及在制备式(I)化合物中有用的某些新型中间体及其制备方法。
• INSOLUBLE COMPLEX OR SOLVATE THEREOF, PHARMACEUTICAL COMPOSTION AND USE THEREOF
  申请人：HEFEI COSOURCE PHARMACEUTICALS INC

  公开号：US20210087144A1

  公开（公告）日：2021-03-25

  The present invention provides a complex of formula (I) or a solvate thereof (wherein n is 1 to 4), a pharmaceutical composition, and use of the pharmaceutical composition in the prevention or treatment of surgical pain, intraoperative pain and postsurgical pain. The technical solution according to the present invention provides a medicament which can be produced by a simple production process and can stably release a local anesthetic in body for a long period. The medicament can be released for at least three days or more, which can prolong the analgesic effect on the postsurgical pain, can be used conveniently by the physician and the patient, and has a good treatment compliance.

  本发明提供了一种具有式（I）的复合物或其溶剂结晶物（其中n为1至4），一种药物组合物，以及药物组合物在预防或治疗手术疼痛、术中疼痛和术后疼痛中的用途。根据本发明的技术方案提供了一种药物，可以通过简单的生产过程生产，并且可以在体内稳定释放局部麻醉剂长时间。该药物可以释放至少三天或更长时间，可以延长对术后疼痛的镇痛效果，可以方便地由医生和患者使用，并具有良好的治疗依从性。
• PROCESS FOR PREPARATION OF (2R)-4-OXO-4-[3- (TRIFLUOROMETHYL)-5,6-DIHYDRO [1,2,4]-TRIAZOLO[4,3-A]PYRAZIN- 7(8H)-YL]-L-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE & NEW IMPURITIES IN PREPARATION THEREOF
  申请人：Kothari Himanshu Madhusudan

  公开号：US20110213149A1

  公开（公告）日：2011-09-01

  The present invention relates to synthesis of β-amino acid derivatives of formula (I) and its salts of formula (Ia) by a novel process. The process comprises the reduction of a protected or unprotected prochiral β-amino acrylic acid or derivative there of, by using borane containing reducing agents at atmospheric pressure. The resulting racemic β-amino compound is resolved to a pure stereoisomer of formula (I), specifically to (2R)-4-oxo-4-[3-Ctrifluoromethyl)-5,6-dihydrol[1,2,4]triazolo[4,3-alpyrazin-7(8H)-yl]-1-(2,4,4-trifluorophenyl)butan-2-amine. In an embodiment the invention disclosed polymorphic forms of formula (I), phosphate salt of formula (I) and also a Dibenzoyl-L-tartaric acid salt of formula (I).

  本发明涉及通过一种新方法合成公式（I）的β-氨基酸衍生物及其公式（Ia）的盐。该方法包括使用含硼烷还原剂在大气压下还原受保护或未保护的β-氨基丙烯酸或其衍生物，生成外消旋β-氨基化合物，然后将其分离成公式（I）的纯立体异构体，具体为（2R）-4-氧代-4-[3-三氟甲基)-5,6-二氢-[1,2,4]三唑[4,3-a]吡嗪-7(8H)-基]-1-(2,4,4-三氟苯基)丁-2-胺。在一个实施例中，本发明揭示了公式（I）的多形式、公式（I）的磷酸盐以及公式（I）的苹果酸二苯甲酰盐。
• PROCESS FOR THE PREPARATION OF R-SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
  申请人：ARJUNAN SANKAR

  公开号：US20100317856A1

  公开（公告）日：2010-12-16

  The present invention provides processes for the preparation of R-sitagliptin and its pharmaceutically acceptable salts thereof.

  本发明提供了用于制备R-西他列汀及其药用可接受的盐的工艺。
• Distinct Selectivity Control in Solar‐Driven Bio‐Based α‐Hydroxyl Acid Conversion: A Comparison of Pt Nanoparticles and Atomically Dispersed Pt on CdS
  作者：Yong You、Peijie Han、Song Song、Wei Luo、Shengnan Zhao、Kaijie Han、Ye Tian、Ning Yan、Xingang Li

  DOI：10.1002/anie.202306452

  日期：2023.10.23

  Distinct selectivity control along with highly efficient H2 production are achieved in photocatalytic conversion of lignocellulose-derived α-hydroxyl acids by tuning the nature of Pt species deposited on CdS.

  通过调节沉积在 CdS 上的 Pt 物质的性质，在木质纤维素衍生的 α-羟基酸的光催化转化中实现了独特的选择性控制和高效的 H 2生产。