(3-bromo-propyl)-trimethyl-ammonium; chloride | 153952-22-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3-bromo-propyl)-trimethyl-ammonium; chloride
• 英文别名: (3-Brom-propyl)-trimethyl-ammonium; Chlorid；3-Bromo-N,N,N-trimethylpropan-1-aminium chloride；3-bromopropyl(trimethyl)azanium;chloride
• CAS: 153952-22-8
• 化学式: C₆H₁₅BrN*Cl
• 分子量: 216.549
• InChiKey: LQDJAZAUZYSHSC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.52
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-bromo-propyl)-trimethyl-ammonium; chloride 、 2,2,5,5-四甲基咪唑烷-4-酮 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成
  参考文献：
  名称：

  Novel N-chloroheterocyclic antimicrobials

  摘要：

  Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.035

文献信息

• Crosslinked cellulosic membrane
  申请人：MILLIPORE CORPORATION

  公开号：EP1468723A1

  公开（公告）日：2004-10-20

  A membrane suitable for conducting macromolecular fluid separations (e.g., protein filtration) is described. The membrane comprises crosslinked polymer formed by an acid catalyzed crosslinking reaction from a cellulosic polymer and a crosslinking agent. In a particular embodiment, the cellulosic polymer is one having substantial crosslinkable hydroxyl moiety content; and the crosslinking agent is one capable of releasing an electrophilic ion in an acidic solution, the electrophile capable of reacting with the hydroxyl moiety of the cellulosic polymer to effect the crosslinking thereof. Good results are obtained by using a multifunctional N-alkyloxy compound as the crosslinking agent.

  描述了一种适用于进行大分子流体分离（如蛋白质过滤）的膜。该膜由纤维素聚合物和交联剂通过酸催化交联反应形成的交联聚合物组成。在一个特定的实施方案中，纤维素聚合物是一种具有大量可交联羟基的聚合物；而交联剂是一种能够在酸性溶液中释放亲电离子的交联剂，亲电离子能够与纤维素聚合物的羟基发生反应以实现交联。使用多功能 N-烷氧基化合物作为交联剂可获得良好的效果。
• Epoxide-crosslinked, charged cellulosic membrane
  申请人：MILLIPORE CORPORATION

  公开号：EP1470854A1

  公开（公告）日：2004-10-27

  A porous synthetic membrane suitable for conducting macromolecular fluid separations (e.g., protein filtration) is described. The ultraporous membrane comprises a surface-charge layer of crosslinked polymer, the crosslinked polymer being formed from a cellulosic polymer and a crosslinking reagent. The cellulosic polymer has substantial crosslinkable hydroxyl moiety content. The crosslinking reagent is a bi- or multi-functional epoxide capable of reacting with and binding to the cellulosic polymer's hydroxyl moieties and has the formula X(CH2)nY, wherein: n is an integer from 1 to 5; X is H2COCH or H2COCHCH2O; and Y is a halogen, H2COCH, or H2COCHCH2O. The porous synthetic membrane has good durability and good protein binding characteristics. Surface charge is provided by covalently binding a charged moiety onto a surface of said layer of crosslinked polymer.

  本文描述了一种适用于进行大分子流体分离（如蛋白质过滤）的多孔合成膜。超多孔膜由交联聚合物表面电荷层组成，交联聚合物由纤维素聚合物和交联试剂形成。纤维素聚合物含有大量可交联羟基。交联试剂是一种能与纤维素聚合物的羟基反应并结合的双官能团或多官能团环氧化物，其式为 X(CH2)nY，其中：n 是 1 到 5 的整数；X 是 H2COCH 或 H2COCHCH2O；Y 是卤素、H2COCH 或 H2COCHCH2O。多孔合成膜具有良好的耐久性和良好的蛋白质结合特性。通过将带电分子共价结合到所述交联聚合物层的表面，可提供表面电荷。
• Lur'e; Fedorowa; Wolkowa, Zhurnal Obshchei Khimii, 1941, vol. 11, p. 739,743
  作者：Lur'e、Fedorowa、Wolkowa

  DOI：——

  日期：——
• Lur'e; Fedorowa, Zhurnal Obshchei Khimii, 1939, vol. 9, p. 2075,2078
  作者：Lur'e、Fedorowa

  DOI：——

  日期：——
• Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0580078B1

  公开（公告）日：1997-10-15