dibutyrylphosphatidylcholine | 63119-35-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: dibutyrylphosphatidylcholine
• 英文别名: dibutyroylphosphatidylcholine；Dibutyryl-α-lecithin；Dibutyrylphosphatidylcholin；1,2-Dibutyryl-sn-glycero-3-phosphorylcholine；1,2-butyryl-sn-glycero-3-phosphocholine；Dibutyroylphosphatidylcholine, dl-；2,3-di(butanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 63119-35-7
• 化学式: C₁₆H₃₂NO₈P
• 分子量: 397.406
• InChiKey: QIJYAMAPPUXBSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-hydroxyethylferrocene 、 dibutyrylphosphatidylcholine 在 catalyst: phospholipase D 作用下， 以 not given 为溶剂， 生成 CH3(CH2)2COCH2CH(OOC(CH2)2CH3)CH2OCH2CH2Fc(1-)
  参考文献：
  名称：

  Synthesis of Redox Active Ferrocene-Modified Phospholipids by Transphosphatidylation Reaction and Chronoamperometry Study of the Corresponding Redox Sensitive Liposome

  摘要：

  The design of stable redox active liposomes where the organometallic electroactive pendent was covalently bound to the phospholipid headgroup through a phospholipase D (PLD)-catalyzed transphosphatidylation reaction between a choline-bearing phospholipid and a primary alcohol containing a ferrocene derivative is reported. The functionalization of a liposome surface with this organometallic redox phospholipid allowed the study of membrane-bound electrochemical reactions, which are important in the design of redox-sensitive liposome delivery systems.

  DOI：

  10.1021/ja105921g