3-(十二烷基氨基)丙烷-1,2-二醇 | 821-91-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-(十二烷基氨基)丙烷-1,2-二醇
• 英文名称: N-(2,3-dihydroxypropyl)-N-dodecylamine
• 英文别名: 1,2-dihydroxy-4-azahexadecane；3-(laurylamino)-1,2-propanediol；3-dodecylamino-1,2-propanediol；N-<β,γ-Dihydroxy-propyl>-N-dodecyl-amin；N-(2,3-dihydroxypropyl)-dodecylamine；3-Laurylamino-1,2-Dihydroxy-Propane；3-(dodecylamino)propane-1,2-diol
• CAS: 821-91-0
• 化学式: C₁₅H₃₃NO₂
• mdl: MFCD00128137
• 分子量: 259.433
• InChiKey: VWGWFMQZURGKKK-UHFFFAOYSA-N

物化性质

• 熔点：
  76.0-76.5 °C
• 沸点：
  396.6±27.0 °C(Predicted)
• 密度：
  0.925±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-羟基十六烷酸甲酯 、 3-(十二烷基氨基)丙烷-1,2-二醇 在 氢氧化钾 作用下， 生成 N-(2,3-dihydroxypropyl)-N-dodecyl-2-hydroxyhexadecanamide
  参考文献：
  名称：

  Synthetic ceramides and their use in cosmetic compostions

  摘要：

  一种新型伪神经酰胺，具有在水溶液中改善的分散性，并且可以通过经济的制造工艺生产。还公开了生产新型伪神经酰胺和含有新型伪神经酰胺的化妆品组合物的方法。

  公开号：

  US05476671A1
• 作为产物：
  描述：

  十二烷基伯胺 、 缩水甘油 生成 3-(十二烷基氨基)丙烷-1,2-二醇
  参考文献：
  名称：

  Synthetic ceramides and their use in cosmetic compostions

  摘要：

  一种新型伪神经酰胺，具有在水溶液中改善的分散性，并且可以通过经济的制造工艺生产。还公开了生产新型伪神经酰胺和含有新型伪神经酰胺的化妆品组合物的方法。

  公开号：

  US05476671A1

文献信息

• Method of inducing a phase transition of a bilayer membrane vesicle
  申请人：Japan Science and Technology Agency

  公开号：US10098841B2

  公开（公告）日：2018-10-16

  Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane. Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle. By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion. In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle.

  提供了一种能够经历相变的双层膜囊泡。该双层膜囊泡包括：(a) 具有6至20个碳原子的脂肪酸盐；(b) 具有6至20个碳原子的脂肪醇或胺化合物；及(c) 能够形成双层膜的人工合成脂质或磷脂。最好，该双层膜囊泡还包含(d) 三级胺作为膜的组分。还提供了一种诱导双层膜囊泡相变的方法，该方法包括将具有在双层膜囊泡界面积累特性的脱水缩合剂或脱水缩合剂前体添加到双层膜囊泡中的步骤。通过使形成分子聚集体的脂质发生化学变化，可以改变分子聚集体的物理性质和形态，并控制膜融合等相变的时机。在膜融合中，例如，融合可以在不泄漏双层膜囊泡内容物的情况下发生。
• Compositions for topical application to skin, hair and nails
  申请人：UNILEVER PLC

  公开号：EP0711558A1

  公开（公告）日：1996-05-15

  Compositions for treating skin, hair and nails which contain 25-hydroxycalciferol in combination with a lipid ingredient. The compositions avoid the toxic effects of 1,25-dihydroxycalciferol, yet attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle 25-hydroxycalciferol and a lipid ingredient.

  含有25-羟基维生素D与脂质成分的用于治疗皮肤、头发和指甲的组合物。这些组合物避免了1,25-二羟基维生素D的毒性效应，同时实现了角质细胞分化并提供了额外的好处。还公开了一种通过在皮肤上涂抹含有25-羟基维生素D和脂质成分的化妆品可接受载体组合物来改善或预防出现皱纹、脱皮、老化、光损伤皮肤的方法。
• Liposoluble compounds useful as magnetic resonance imaging agents
  申请人：ImaR.sub.x Pharmaceutical Corp.

  公开号：US05466438A1

  公开（公告）日：1995-11-14

  Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.

  新型含顺磁离子和长脂链化合物的络合物已经被合成用作磁共振成像对比剂。这些新型脂溶性对比剂可以单独或与脂质、悬浮剂或其他添加剂一起使用。脂质可以是脂质体、胶束或脂质乳液的形式。本发明的对比剂在肝脏、血液池和网状内皮系统的磁共振成像中具有特殊用途。
• Molecular Aggregate Capable of Undergoing Phase Transition by Dehydrating Condensation and Method of Phase Transition Thereof
  申请人：Kunishima Munetaka

  公开号：US20090023003A1

  公开（公告）日：2009-01-22

  Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane. Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle. By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion. In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle.

  提供的是一种能够经历相变的双层膜囊泡。该双层膜囊泡包括：(a)一种含有6到20个碳原子的脂肪酸盐；(b)一种具有6到20个碳原子的脂肪链的醇或胺化合物；以及(c)一种能够形成双层膜的人工合成脂质或磷脂。最好的情况下，这种双层膜囊泡还包含(d)作为膜组分的三级胺。还提供了一种诱导双层膜囊泡相变的方法，该方法包括向双层膜囊泡中加入具有在界面处积聚性质的脱水缩合剂或脱水缩合剂前体的步骤。通过使形成分子聚集体的脂质发生化学变化，可以改变分子聚集体的物理性质和形态，并控制膜融合等相变的时机。在膜融合中，例如，可以在不泄漏双层膜囊泡内容物的情况下进行融合。
• Method of Inducing a Phase Transition of a Bilayer Membrane Vesicle
  申请人：JAPAN SCIENCE AND TECHNOLOGY AGENCY

  公开号：US20130251788A1

  公开（公告）日：2013-09-26

  Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane. Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle. By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion. In the membrane fusion, for example, fusion can occur without leakage of the contents of the bilayer membrane vesicle.

  提供的是一种能够经历相变的双层膜小泡。该双层膜小泡包括：(a) 6至20个碳原子的脂肪酸盐；(b) 具有6至20个碳原子的脂肪链的醇或胺化合物；以及(c) 能够形成双层膜的人工合成脂质或磷脂。最好，该双层膜小泡还包含(d) 作为膜组分的三级胺。还提供了一种诱导双层膜小泡相变的方法，该方法包括向双层膜小泡添加具有在界面处积累性质的脱水缩合剂或脱水缩合剂前体的步骤。通过使形成分子聚集体的脂质发生化学变化，可以改变分子聚集体的物理性质和形态，并控制膜融合等相变的时间。例如，在膜融合中，可以在不泄漏双层膜小泡内容物的情况下发生融合。