2-benzyl-3,4-dihydro-2H-[2,7]naphthyridin-1-on | 858120-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-benzyl-3,4-dihydro-2H-[2,7]naphthyridin-1-on
• 英文别名: 2-benzyl-3,4-dihydro-2H-[2,7]naphthyridine-1-one；3,4-Dihydro-2-(phenylmethyl)-2,7-naphthyridin-1(2H)-one；2-benzyl-3,4-dihydro-2,7-naphthyridin-1-one
• CAS: 858120-60-2
• 化学式: C₁₅H₁₄N₂O
• 分子量: 238.289
• InChiKey: HJQKGYUXRJSBBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] NOUVEAUX DERIVES DE PYRIDINE, LEUR PROCEDE DE PREPARATION ET COMPOSITION PHARMACEUTIQUE EN CONTENANT
  申请人：SK CHEMICALS CO LTD

  公开号：WO2005063768A1

  公开（公告）日：2005-07-14

  This invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

  这项发明涉及具有抑制细胞因子产生作用的新型吡啶衍生物，这些细胞因子参与炎症反应，因此表明其可用作治疗与炎症、免疫、慢性炎症相关疾病的治疗剂，同时具有抗炎和镇痛作用的药剂。此外，这项发明涉及制造该化合物的方法和含有该化合物的药物组合物。
• Novel Pyridine Derivatives, a Process for Their Preparation and a Pharmaceutical Composition Containing the Same
  申请人：Kim Ook Hyung

  公开号：US20070254909A1

  公开（公告）日：2007-11-01

  The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

  本发明涉及一种新型吡啶衍生物，具有抑制细胞因子产生的作用，这些细胞因子参与炎症反应，从而表明它们在治疗与炎症、免疫、慢性炎症相关的疾病中具有治疗作用，同时具有抗炎和镇痛作用的药剂。此外，本发明还涉及制造该药物的方法和含有该药物的药物组合物。
• NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：SK Chemicals, Co., Ltd.

  公开号：EP1706412A1

  公开（公告）日：2006-10-04
• EP1706412A4
  申请人：——

  公开号：EP1706412A4

  公开（公告）日：2009-03-18
• US7601736B2
  申请人：——

  公开号：US7601736B2

  公开（公告）日：2009-10-13