ethyl hydrogen (Z)-dec-1-en-3-ynylphosphonate | 862206-11-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: ethyl hydrogen (Z)-dec-1-en-3-ynylphosphonate
• 英文别名: [(Z)-dec-1-en-3-ynyl]-ethoxyphosphinic acid
• CAS: 862206-11-9
• 化学式: C₁₂H₂₁O₃P
• 分子量: 244.271
• InChiKey: IUKSESUHNFGHIZ-QXMHVHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl hydrogen (Z)-dec-1-en-3-ynylphosphonate 在 silver carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 2-ethoxy-6-hexyl-1,2-oxaphosphorin 2-oxide
  参考文献：
  名称：

  Synthesis of 2H-1,2-Oxaphosphorin 2-Oxides via Ag₂CO₃-Catalyzed Cyclization of (Z)-2-Alken-4-ynylphosphonic Monoesters

  摘要：

  Six new 2-ethoxy-2H-1,2-oxaphosphorin 2-oxides were synthesized with high regioselectivity in good yields via Ag2CO3-Catalyzed cyclization of (2)-2-alken-4-ynylphosphonic monoesters in CH2Cl2 at room temperature. This cyclization of P-OH to substituted alkynes is reported for the first time. The products are a class of phosphorus heterocycles with potential use and are heretofore prepared with difficulty.

  DOI：

  10.1021/ol051126+
• 作为产物：
  描述：

  diethyl (Z)-dec-1-en-3-ynylphosphonate 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 ethyl hydrogen (Z)-dec-1-en-3-ynylphosphonate
  参考文献：
  名称：

  Synthesis of 2H-1,2-Oxaphosphorin 2-Oxides via Ag₂CO₃-Catalyzed Cyclization of (Z)-2-Alken-4-ynylphosphonic Monoesters

  摘要：

  Six new 2-ethoxy-2H-1,2-oxaphosphorin 2-oxides were synthesized with high regioselectivity in good yields via Ag2CO3-Catalyzed cyclization of (2)-2-alken-4-ynylphosphonic monoesters in CH2Cl2 at room temperature. This cyclization of P-OH to substituted alkynes is reported for the first time. The products are a class of phosphorus heterocycles with potential use and are heretofore prepared with difficulty.

  DOI：

  10.1021/ol051126+

文献信息

• Synthesis of 2<i>H</i>-1,2-Oxaphosphorin 2-Oxides via Ag₂CO₃-Catalyzed Cyclization of (<i>Z</i>)-2-Alken-4-ynylphosphonic Monoesters
  作者：Ai-Yun Peng、Yi-Xiang Ding

  DOI：10.1021/ol051126+

  日期：2005.7.1

  Six new 2-ethoxy-2H-1,2-oxaphosphorin 2-oxides were synthesized with high regioselectivity in good yields via Ag2CO3-Catalyzed cyclization of (2)-2-alken-4-ynylphosphonic monoesters in CH2Cl2 at room temperature. This cyclization of P-OH to substituted alkynes is reported for the first time. The products are a class of phosphorus heterocycles with potential use and are heretofore prepared with difficulty.