Tandem Catalysis: A Ring-Closing Metathesis Followed by Dehydrogenative Oxidation to Afford Substituted Indenones
作者:Willem A. van Otterlo、E. Mabel Coyanis、Jenny-Lee Panayides、Charles B. de Koning、Manuel A. Fernandes
DOI:10.1055/s-2005-862356
日期:——
Grubbs second generation catalyst converts substituted 1-(2-propenylphenyl)prop-2-en-1-ols into substituted indenols or indenones depending on the reaction conditions employed. The formation of indenones represents the first example of a tandem ruthenium-mediated ring-closing metathesis-dehydrogenative oxidation reaction.
Ring-closing metathesis for the synthesis of substituted indenols, indenones, indanones and indenes: Tandem RCM-dehydrogenative oxidation and RCM-formal redox isomerization
作者:E. Mabel Coyanis、Jenny-Lee Panayides、Manuel A. Fernandes、Charles B. de Koning、Willem A.L. van Otterlo
DOI:10.1016/j.jorganchem.2006.08.074
日期:2006.12
temperature and catalyst loadings) for the metathesis reactions resulted in the formation of substituted indenones, formed by a tandem RCM-dehydrogenative oxidation in the absence of a hydrogen acceptor. Further manipulations of the reaction conditions generated two substituted indanones by way of a tandem RCM-formal redox isomerization sequence. Finally the synthesis of some substituted indenes was accomplished