N,Na(2)-[1,2-Ethanediylbis(oxy-2,1-ethanediyl)]bis[2-propanamine] | 124477-30-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,Na(2)-[1,2-Ethanediylbis(oxy-2,1-ethanediyl)]bis[2-propanamine]
• 英文别名: N-[2-[2-[2-(propan-2-ylamino)ethoxy]ethoxy]ethyl]propan-2-amine
• CAS: 124477-30-1
• 化学式: C₁₂H₂₈N₂O₂
• 分子量: 232.36
• InChiKey: OXLRHYVCQQKZRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METAP2 inhibitors and methods of treating obesity
  申请人：SynDevRx, Inc.

  公开号：US10588904B2

  公开（公告）日：2020-03-17

  The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing, causing or increasing weight loss, treating obesity and/or treating metabolic syndrome utilizing the modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of improving insulin sensitivity and glycemic control, reducing insulin levels and/or improving leptin sensitivity utilizing the modified or polymer conjugated MetAP2 inhibitors.

  本发明涉及改性或聚合物共轭 MetAP2 抑制剂。本发明还涉及利用改性或聚合物共轭 MetAP2 抑制剂预防、诱导、导致或增加体重减轻、治疗肥胖和/或治疗代谢综合征的方法。本发明还涉及利用改性或聚合物共轭 MetAP2 抑制剂改善胰岛素敏感性和血糖控制、降低胰岛素水平和/或改善瘦素敏感性的方法。
• Treatment for tumors driven by metabolic dysfunction
  申请人：SynDevRx, Inc.

  公开号：US10646463B2

  公开（公告）日：2020-05-12

  The present disclosure relates to modified or polymer conjugated MetAP2 inhibitors. The present disclosure also relates to methods of treating metabolically-driven diseases and disorders, such as certain cancers.

  本公开涉及修饰的或聚合物共轭的 MetAP2 抑制剂。本公开还涉及治疗代谢驱动的疾病和失调（如某些癌症）的方法。
• Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
  申请人：Vanderbilt University

  公开号：US10610598B2

  公开（公告）日：2020-04-07

  Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文公开了用于给药的缩水甘油基聚合物、纳米颗粒及其相关方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• Acid gas enrichment method and system
  申请人：BASF SE

  公开号：US10875769B2

  公开（公告）日：2020-12-29

  A process for treating an H2S- and CO2-comprising fluid stream, in which a) the fluid stream is treated in a first absorber at a pressure of 10 to 150 bar with a first substream of a regenerated H2S-selective absorbent to obtain a treated fluid stream and an H2S-laden absorbent; b) the H2S-laden absorbent is heated by indirect heat exchange with regenerated H2S-selective absorbent; c) the heated H2S-laden absorbent is decompressed to a pressure of 1.2 to 10 bar in a low-pressure decompression vessel to obtain a first CO2-rich offgas and a partly regenerated absorbent; d) the partly regenerated absorbent is regenerated in a desorption column to obtain an H2S-rich offgas and regenerated absorbent; e) the H2S-rich offgas is fed to a Claus unit and the offgas from the Claus unit is fed to a hydrogenation unit to obtain hydrogenated Claus tail gas; f) the hydrogenated Claus tail gas and the first CO2-rich offgas are treated in a second absorber at a pressure of 1 to 4 bar with a second substream of the regenerated H2S-selective absorbent to obtain a second CO2-rich offgas and a second H2S-laden absorbent; and g) the second H2S-laden absorbent is guided into the first absorber. Also described is a plant suitable for performance of the process. The process is notable for a low energy requirement.

  一种处理含有 H2S 和 CO2 的流体流的工艺，其中 a) 在压力为 10 至 150 巴的第一吸收器中，用再生的 H2S 选择性吸收剂的第一子流处理流体流，得到处理过的流体流和含有 H2S 的吸收剂；b) 通过与再生的 H2S 选择性吸收剂进行间接热交换，加热含有 H2S 的吸收剂；c) 在低压减压容器中，将加热的含有 H2S 的吸收剂减压至压力为 1.2至10巴的低压减压容器中减压，得到富含CO2的第一种尾气和部分再生的吸收剂；d) 部分再生的吸收剂在解吸塔中再生，得到富含H2S的尾气和再生的吸收剂；e) 将富含H2S的尾气送入克劳斯装置，将克劳斯装置的尾气送入加氢装置，得到加氢克劳斯尾气；f) 将氢化克劳斯尾气和第一种富含 CO2 的尾气在压力为 1 至 4 巴的第二吸收器中用再生 H2S 选择性吸收剂的第二子流进行处理，以获得第二种富含 CO2 的尾气和第二种富含 H2S 的吸收剂；以及 g) 将第二种富含 H2S 的吸收剂导入第一吸收器。此外，还介绍了适用于该工艺的设备。该工艺的显著特点是能耗低。
• Gene delivery carrier
  申请人：Massachusetts Institute of Technology

  公开号：US11041069B2

  公开（公告）日：2021-06-22

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

  本文公开了制备和利用聚（β-氨基酯）（PBAE）聚合物的方法、组合物、试剂、系统和试剂盒，这些聚合物是通过本文公开的二丙烯酸酯和胺的迈克尔加成反应合成的。不同的实施例利用内酯和内酯衍生物生成二丙烯酸酯化合物。事实证明，PBAE 聚合物是一种有效的可生物降解载体，可用于传递有机分子、无机分子、核酸、蛋白质、肽、多核苷酸、靶向剂、同位素标记的化合物、疫苗或免疫制剂等制剂。