1-Methyl-4-(1-phenyl-2-piperazin-1-ylethyl)piperazine | 486439-00-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Methyl-4-(1-phenyl-2-piperazin-1-ylethyl)piperazine
• CAS: 486439-00-3
• 化学式: C₁₇H₂₈N₄
• 分子量: 288.436
• InChiKey: RAAFFHQOZBQNGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  21.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 苯丙酮 、 1-Methyl-4-(1-phenyl-2-piperazin-1-ylethyl)piperazine 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 2-Methyl-3-{4-[2-(4-methyl-piperazin-1-yl)-2-phenyl-ethyl]-piperazin-1-yl}-1-phenyl-propan-1-one
  参考文献：
  名称：

  Structure−Activity Relationship of (1-Aryl-2-piperazinylethyl)piperazines:  Antagonists for the AGRP/Melanocortin Receptor Binding

  摘要：

  Agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin action.(1) In the hypothalamus, melanocortin peptide agonists act as satiety-inducing factors that mediate their action through the melanocortin-4 receptor (MC4R) whereas AGRP is an opposing orexigenic agent. Novel inhibitors of the AGRP/MC4 binding based on (piperazinylethyl)piperazines were prepared, and their structure-activity relationship was established.

  DOI：

  10.1021/jm0255522
• 作为产物：
  描述：

  N-甲基哌嗪 在 氢氧化钾 作用下， 以 乙醇 、 苯 为溶剂， 生成 1-Methyl-4-(1-phenyl-2-piperazin-1-ylethyl)piperazine
  参考文献：
  名称：

  Structure−Activity Relationship of (1-Aryl-2-piperazinylethyl)piperazines:  Antagonists for the AGRP/Melanocortin Receptor Binding

  摘要：

  Agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin action.(1) In the hypothalamus, melanocortin peptide agonists act as satiety-inducing factors that mediate their action through the melanocortin-4 receptor (MC4R) whereas AGRP is an opposing orexigenic agent. Novel inhibitors of the AGRP/MC4 binding based on (piperazinylethyl)piperazines were prepared, and their structure-activity relationship was established.

  DOI：

  10.1021/jm0255522

文献信息

• Structure−Activity Relationship of (1-Aryl-2-piperazinylethyl)piperazines:  Antagonists for the AGRP/Melanocortin Receptor Binding
  作者：Premilla N. Arasasingham、Christopher Fotsch、Xiaohu Ouyang、Mark H. Norman、Michael G. Kelly、Kevin L. Stark、Bill Karbon、Clarence Hale、James W. Baumgartner、Martha Zambrano、Janet Cheetham、Nuria A. Tamayo

  DOI：10.1021/jm0255522

  日期：2003.1.1

  Agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin action.(1) In the hypothalamus, melanocortin peptide agonists act as satiety-inducing factors that mediate their action through the melanocortin-4 receptor (MC4R) whereas AGRP is an opposing orexigenic agent. Novel inhibitors of the AGRP/MC4 binding based on (piperazinylethyl)piperazines were prepared, and their structure-activity relationship was established.