((E)-1,2-Dimethyl-3-tributylstannanyl-allyl)-phosphonic acid diethyl ester | 142387-19-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: ((E)-1,2-Dimethyl-3-tributylstannanyl-allyl)-phosphonic acid diethyl ester
• 英文别名: tributyl-(3-diethoxyphosphoryl-2-methylbut-1-enyl)stannane
• CAS: 142387-19-7
• 化学式: C₂₁H₄₅O₃PSn
• 分子量: 495.27
• InChiKey: ILVLFNAZPUJTGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.98
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ((E)-1,2-Dimethyl-3-tributylstannanyl-allyl)-phosphonic acid diethyl ester 在 Pd(CH₃)2Cl₂ 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2Z,4E,6E,8E)-(S)-11-(tert-Butyl-diphenyl-silanyloxy)-3,7,8,10-tetramethyl-undeca-2,4,6,8-tetraenenitrile
  参考文献：
  名称：

  Towards the Synthesis of Calyculin: A Synthetic Intermediate Corresponding to the C(26)-C(37) Fragment

  摘要：

  The synthetic intermediate 2 corresponding to the C(26)-C(37) fragment of calyculin A (1) has been synthesized. Key transformations include the efficient one-pot construction of the oxazole system embedded in 1 without epimerization-alpha [C(30)] to the ring, and the in situ formation of the dimethylamine by opening an N-methyllactam with Meerwein's reagent and trapping the resultant methylamine with formaldehyde.

  DOI：

  10.1016/0040-4039(92)88107-g

文献信息

• Tanimoto, Norihiko; Gerritz, Samuel W.; Sawabe, Akiyoshi, Angewandte Chemie, 1994, vol. 106, # 6, p. 674 - 677
  作者：Tanimoto, Norihiko、Gerritz, Samuel W.、Sawabe, Akiyoshi、Noda, Takeshi、Filla, Sandra A.、Masamune, Satoru

  DOI：——

  日期：——
• Towards the Synthesis of Calyculin: A Synthetic Intermediate Corresponding to the C(26)-C(37) Fragment
  作者：Henry A. Vaccaro、Daniel E. Levy、Akiyoshi Sawabe、Thomas Jaetsch、Satoru Masamune

  DOI：10.1016/0040-4039(92)88107-g

  日期：1992.4

  The synthetic intermediate 2 corresponding to the C(26)-C(37) fragment of calyculin A (1) has been synthesized. Key transformations include the efficient one-pot construction of the oxazole system embedded in 1 without epimerization-alpha [C(30)] to the ring, and the in situ formation of the dimethylamine by opening an N-methyllactam with Meerwein's reagent and trapping the resultant methylamine with formaldehyde.