1-[(E)-2-phenylethenyl]-2-prop-2-enoxybenzene | 1435743-29-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[(E)-2-phenylethenyl]-2-prop-2-enoxybenzene
• CAS: 1435743-29-5
• 化学式: C₁₇H₁₆O
• 分子量: 236.313
• InChiKey: CXWYHCHORRCWAO-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-苯乙烯基苯醇 、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以79%的产率得到1-[(E)-2-phenylethenyl]-2-prop-2-enoxybenzene
  参考文献：
  名称：

  Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives

  摘要：

  We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the reverse transcriptase/polymerase chain reaction experiment that these stilbene derivatives down-regulate the expression of the gene related to the production of the angiogenesis factor VEGF in cancer cells. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.03.072

文献信息

• Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives
  作者：Rosa Martí-Centelles、Rocío Cejudo-Marín、Eva Falomir、Juan Murga、Miguel Carda、J. Alberto Marco

  DOI：10.1016/j.bmc.2013.03.072

  日期：2013.6

  We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine aorta endothelial cells. In addition, it has been confirmed through the reverse transcriptase/polymerase chain reaction experiment that these stilbene derivatives down-regulate the expression of the gene related to the production of the angiogenesis factor VEGF in cancer cells. (C) 2013 Elsevier Ltd. All rights reserved.