N-Butyl-pentanamidine | 198065-83-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Butyl-pentanamidine
• 英文别名: N'-butylpentanimidamide
• CAS: 198065-83-7
• 化学式: C₉H₂₀N₂
• 分子量: 156.271
• InChiKey: QHAGAGQOWMCLRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-bromo-3-methoxy-2-propenenitrile 、 N-Butyl-pentanamidine 在 potassium carbonate 作用下， 以 氯仿 、 水 为溶剂， 反应 18.0h， 以45%的产率得到2,3-Dibutyl-3H-imidazole-4-carbonitrile
  参考文献：
  名称：

  A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan

  摘要：

  A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazolecarboxaldehydes ranging from 85:15 to 100: 0. This methodology could be extended with similar results to the synthesis of imidazole-g-nitriles by the reaction of 2-bromo-3-methoxy-2-propenenitrile with N-monosubstituted amidines.

  DOI：

  10.1021/jo971304f
• 作为产物：
  描述：

  戊亚氨酸甲酯 、 正丁胺 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 N-Butyl-pentanamidine
  参考文献：
  名称：

  A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan

  摘要：

  A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazolecarboxaldehydes ranging from 85:15 to 100: 0. This methodology could be extended with similar results to the synthesis of imidazole-g-nitriles by the reaction of 2-bromo-3-methoxy-2-propenenitrile with N-monosubstituted amidines.

  DOI：

  10.1021/jo971304f

文献信息

• [EN] CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES<br/>[FR] CONJUGAISON CHIMIOSÉLECTIVE D'UN THIOL AVEC DES ALCÈNE- OU ALCYNE-PHOSPHONAMIDATES
  申请人：FORSCHUNGSVERBUND BERLIN EV

  公开号：WO2018041985A1

  公开（公告）日：2018-03-08

  Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).

  揭示了新颖的结合物和其制备方法。一种制备烯烃或炔烃磷酰胺酯的方法包括以下步骤：(I)将式（III）的化合物与式（IV）的叠氮化合物反应，制备出式（V）的化合物，将式（V）的化合物与式（VI）的含硫醇分子反应，得到式（VII）的化合物。
• PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS
  申请人：Dellinger Douglas J.

  公开号：US20100076183A1

  公开（公告）日：2010-03-25

  A nucleoside monomer that is protected by a thionocarbamate protecting group is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.

  提供了一种由硫代氨基甲酸酯保护基保护的核苷单体，以及使用该核苷单体制备多核苷酸的方法。还提供了一种利用二胺去保护受保护多核苷酸的多核苷酸合成方法。
• [EN] SOLID-PHASE PURIFICATION OF SYNTHETIC NUCLEIC ACID SEQUENCES<br/>[FR] PURIFICATION EN PHASE SOLIDE DE SÉQUENCES D'ACIDES NUCLÉIQUES SYNTHÉTIQUES
  申请人：US HEALTH

  公开号：WO2018005630A1

  公开（公告）日：2018-01-04

  The invention provides a compound of the formula (I), and a capture support of the formula (9), wherein R1, R2, R3, R6, A, B, D, E, J, K, Q, W, and Z are as defined herein. The invention also provides a method of purifying an oligonucleotide or an oligonucleotide analog composed of "b" nucleotides from a mixture comprising the oligonucleotide or oligonucleotide analog and at least one oligonucleotide or oligonucleotide analog composed of "a" nucleotides, wherein b ≠ a, comprising use of the compound and the capture support.

  该发明提供了一个公式(I)的化合物，以及一个公式(9)的捕获支持物，其中R1、R2、R3、R6、A、B、D、E、J、K、Q、W和Z如本文所定义。该发明还提供了一种从包括寡核苷酸或寡核苷酸类似物和至少一种由"a"核苷酸组成的寡核苷酸或寡核苷酸类似物的混合物中纯化由"b"核苷酸组成的寡核苷酸或寡核苷酸类似物的方法，其中b ≠ a，包括使用该化合物和捕获支持物。
• COMPOUND, NUCLEIC ACID, LABELING SUBSTANCE, AND DETECTION METHOD
  申请人：KABUSHIKI KAISHA DNAFORM

  公开号：US20150252070A1

  公开（公告）日：2015-09-10

  The present invention provides a compound represented by the following chemical formula (I); a tautomer or stereoisomer of the compound; or a salt of the compound, the tautomer, or the stereoisomer. In the chemical formula (I), R 1 and R 2 are each a Group 1 element or a protecting group of an amino group and may be identical to or different from each other, or alternatively, R 1 and R 2 together may form a protecting group of an amino group. R 3 is a Group 1 element or a protecting group of a hydroxy group. R 4 is a Group 1 element or —PR 5 R 6 R 7 R 8 (R 5 , R 6 , R 7 , and R 8 are each a Group 1 element, a lone electron pair, a Group 16 element, a Group 17 element, or a protecting group of a phosphorus atom, and may be identical to or different from each other). J is a hydrogen atom or an arbitrary atomic group, A is a hydrogen atom, a hydroxy group, an alkyl group, an aralkyl group, an alkoxy group, an electron-withdrawing group, a silylene group, or a sulfide group, or alternatively, J and A together may form a linker. L is a single bond or a linker (a linking atom or a linking atomic group), the main chain length (the number of main chain atoms) of the linker is arbitrary, L may or may not contain each of C, N, O, S, P, and Si in the main chain, and may or may not contain each of a single bond, a double bond, a triple bond, an amide bond, an ester bond, a disulfide bond, an imino group, an ether bond, a thioether bond, and a thioester bond in the main chain. Z is an atomic group that can form a peptide bond with a labeling compound, or is an atom or atomic group including a label.

  本发明提供了以下化学式（I）所代表的化合物；该化合物的互变异构体或立体异构体；或者该化合物、互变异构体或立体异构体的盐。在化学式（I）中，R1和R2分别是第1族元素或氨基的保护基，它们可以相同也可以不同，或者R1和R2可以一起形成氨基的保护基。R3是第1族元素或羟基的保护基。R4是第1族元素或-PR5R6R7R8（R5、R6、R7和R8分别是第1族元素、孤立电子对、第16族元素、第17族元素或磷原子的保护基，它们可以相同也可以不同）。J是氢原子或任意的原子基团，A是氢原子、羟基、烷基、芳基烷基、烷氧基、吸电子基团、硅烷基团或硫化物基团，或者J和A可以一起形成连接基团。L是单键或连接基团（连接原子或连接原子基团），连接基团的主链长度（主链原子数）是任意的，L可能包含或不包含主链中的C、N、O、S、P和Si，也可能包含或不包含主链中的单键、双键、三键、酰胺键、酯键、二硫键、亚胺基团、醚键、硫醚键和硫酯键。Z是能与标记化合物形成肽键的原子基团，或者是包括标记的原子或原子基团。
• Nucleotide analogs with six membered rings
  申请人：Roche Diagnostics GmbH

  公开号：EP1466919A1

  公开（公告）日：2004-10-13

  The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used.

  本发明涉及包含能够被并入核酸的六元环的化合物。特别是，这个六元环是环己烷、环己烯、四氢吡喃、四氢硫吡喃或哌啶的衍生物。这些化合物可以用于构建寡聚合物化合物。该发明还涉及这些寡聚合物化合物用于杂交和作为探针的用途。此外，提供了检测核酸的方法，其中使用了这些寡聚合物化合物。