RGDSPASSKP

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: RGDSPASSKP
• 英文别名: H-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH；(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
• 化学式: C₄₀H₆₈N₁₄O₁₆
• 分子量: 1001.06
• InChiKey: JMBLPSUDFRAOLU-SMNCUOCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.8
• 重原子数：
  70
• 可旋转键数：
  30
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  496
• 氢给体数：
  16
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  在 三乙基硅烷 、 水 、 三氟乙酸 作用下， 反应 2.0h， 以2 mg的产率得到RGDSPASSKP
  参考文献：
  名称：

  Targeting of polyamidoamine–DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation

  摘要：

  Two new methods for the modular synthesis of targeted gene delivery systems are reported. The PEGylated polyamidoamine DMEDA-PEG-DMEDA-(MBA-DMEDA)(n+1)-PEG-DMEDA 3 was sequentially modified to contain an integrin-binding peptide ligand via the Staudinger ligation. The conjugation of the ligand was achieved either before particle complexation (precomplexation) or after particle complexation (postcomplexation). Comparison of the two systems showed that postcomplexation strategy led to small and discrete toroidal nanoparticles whilst the precomplexation particles showed loose complexes. The targeted particles showed an increased uptake into cells compared to unmodified complexes however no significant increase in transfection was seen. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.023