Formylphosphonsaeure | 55217-41-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Formylphosphonsaeure
• 英文别名: phosphono formaldehyde；formylphosphonic acid；phosphonoketone
• CAS: 55217-41-9
• 化学式: CH₃O₄P
• 分子量: 110.006
• InChiKey: DEBRGDVXKPMWQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Formylphosphonsaeure 、 硝酸 生成 甲酸
  参考文献：
  名称：

  STRUNIN, B. P.;XIZBULLIN, F. F., ZH. OBSHCH. XIMII, 59,(1989) N, S. 537-543

  摘要：

  DOI：

文献信息

• Process for preparing glyphosate and glyphosate derivatives
  申请人：Monsanto Company

  公开号：US04568432A1

  公开（公告）日：1986-02-04

  A process for preparing glyphosate and derivatives of related structure. A precursor primary or secondary amine, such as glycine, is condensed with a carbonyl compound, such as formylphosphonic acid or its acetals, and the condensation product is reduced to produce the desired product.

  一种制备草甘膦及相关结构衍生物的方法。首先将前体原初或次级胺（如甘氨酸）与羰基化合物（如甲酰磷酸或其缩醛）缩合，然后还原缩合产物以制备所需的产物。
• Process for the preparation of N-phosphonomethylglycine and derivatives thereof
  申请人：Coleman P. James

  公开号：US20050054871A1

  公开（公告）日：2005-03-10

  N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.

  N-磷酸甲基胺类物质是通过将胺底物与卤代甲基膦酸或其盐、羟甲基膦酸或其盐或羟甲基膦酸的脱水自酯二聚体、三聚体或寡聚体反应而制得。根据该过程可以制备的产品包括N-磷酸甲基氨基羧酸，如草甘膦，N-磷酸甲基氨基醇，如羟乙基氨甲基膦酸和N-酰基氨基甲基膦酸，如N-氨基甲基膦酸。某些反应在过量胺反应物的情况下进行，以推动转化而避免过多的双(N-磷酸甲基)胺副产物的形成。其他反应使用次级胺底物（例如亚氨基乙酸）并且可以在卤代甲基氨基膦酸或羟基氨基膦酸与次级胺底物的实质等摩尔比下进行，而不会显著形成双(磷酸甲基)胺副产物。此外，还公开了一种通过共沸脱水制备羟甲基膦酸自酯二聚体、三聚体和寡聚体的方法。
• Preparation of formylphosphonic acid from tertiary aminomethylphosphonic acid N-oxides
  申请人：Monsanto Co.

  公开号：US06274760B1

  公开（公告）日：2001-08-14

  Formylphosphonic acid derivatives are prepared by the catalytic decomposition of a (phosphonomethyl)amine N-oxide compound to form the formylphosphonic acid derivative and a dephosphonomethylated amine.

  Formylphosphonic acid derivatives是通过催化分解(phosphonomethyl)amine N-oxide化合物制备的，以形成formylphosphonic acid衍生物和dephosphonomethylated amine。
• STRUNIN, B. P.;XIZBULLIN, F. F., ZH. OBSHCH. XIMII, 59,(1989) N, S. 537-543
  作者：STRUNIN, B. P.、XIZBULLIN, F. F.

  DOI：——

  日期：——
• ROGERS, T. E.
  作者：ROGERS, T. E.

  DOI：——

  日期：——