Depreotide trifluoroacetate | 951756-09-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: Depreotide trifluoroacetate
• 英文别名: (2S)-6-amino-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-[[2-[2-[(2S,5S,8S,11R,14S,17S)-14-(4-aminobutyl)-5-benzyl-8-[(4-hydroxyphenyl)methyl]-11-(1H-indol-3-ylmethyl)-4-methyl-3,6,9,12,15,18-hexaoxo-17-propan-2-yl-1,4,7,10,13,16-hexazacyclooctadec-2-yl]ethylsulfanyl]acetyl]amino]propanoyl]amino]hexanoyl]amino]-3-sulfanylpropanoyl]amino]hexanamide;2,2,2-trifluoroacetic acid
• CAS: 951756-09-5
• 化学式: C67H97F3N16O14S2
• 分子量: 1471.7
• InChiKey: ULBLQSNGKAZIES-KTABZWLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.72
• 重原子数：
  102
• 可旋转键数：
  34
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  529
• 氢给体数：
  18
• 氢受体数：
  23

文献信息

• RADIOISOTOPE TRITHIOL COMPLEXES
  申请人：JURISSON SILVIA S.

  公开号：US20150283274A1

  公开（公告）日：2015-10-08

  The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.

  本发明涉及一系列稳定的放射性同位素三硫醇配合物，提供了一种简化的途径，可直接将低浓度存在的放射性同位素配合。在某些实施例中，该配合物含有一个连接结构域，配置为将放射性同位素三硫醇配合物与靶向载体结合。该发明还涉及一种将放射性同位素连接到三硫醇化合物以形成放射性同位素三硫醇配合物的新方法。这种创新的放射性同位素三硫醇配合物可用于各种应用，包括核医学诊断和/或治疗。
• COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS
  申请人：The Regents of The University of Michigan

  公开号：EP3471778A2

  公开（公告）日：2019-04-24
• COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE
  申请人：The Regents Of The University Of Michigan

  公开号：EP3820534A1

  公开（公告）日：2021-05-19
• US9427483B2
  申请人：——

  公开号：US9427483B2

  公开（公告）日：2016-08-30
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR ADMINISTRER DES AGENTS BIOMACROMOLÉCULAIRES
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2017223085A2

  公开（公告）日：2017-12-28

  The present invention relates to nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).