7-Chloro-1-methyl-1,2,3,4-tetrahydroquinoxaline | 1369154-32-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 7-Chloro-1-methyl-1,2,3,4-tetrahydroquinoxaline
• 英文别名: 6-chloro-4-methyl-2,3-dihydro-1H-quinoxaline
• CAS: 1369154-32-4
• 化学式: C₉H₁₁ClN₂
• 分子量: 182.65
• InChiKey: LKLTVMLJYSEUSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS
  申请人：Relay Therapeutics, Inc.

  公开号：US20200172546A1

  公开（公告）日：2020-06-04

  The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure