Esuberaprost Sodium | 152695-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: Esuberaprost Sodium
• 英文别名: sodium;4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S,4S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
• CAS: 152695-53-9
• 化学式: C24H29NaO5
• 分子量: 420.5
• InChiKey: YTCZZXIRLARSET-ZTWNIFTGSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.04
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Therapeutic Agent and Treatment Method for Ameliorating Uremia
  申请人：Takenaka Masahiko

  公开号：US20090143463A1

  公开（公告）日：2009-06-04

  A therapeutic agent and a treatment method for uremia of human and animals, which therapeutic agent can be easily taken, has lower side effects, and which is not expensive in view of medical economics, are disclosed. The therapeutic agent for uremia in patients suffering from chronic renal failure comprises as an effective ingredient a prostaglandin I 2 derivative having a specific structure, such as beraprost sodium. The therapeutic agent for uremia ameliorates the uremia concurred in patients with chronic renal failure without accompanying side effects, and restoration of decreased appetite, improvements in activities, increase in body weight and the like are achieved. The therapeutic effect of uremia is clear alleviation or disappearance of symptoms of uremia grasped as clinical symptoms, observed in the state of renal failure, especially even in spite of the state wherein the decrease in renal function is progressed.
• US9783518B2
  申请人：——

  公开号：US9783518B2

  公开（公告）日：2017-10-10
• US9913825B2
  申请人：——

  公开号：US9913825B2

  公开（公告）日：2018-03-13