4-chloropyrimido[5,4-c]isoquinoline | 1421504-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 4-chloropyrimido[5,4-c]isoquinoline
• 英文别名: 4-Chloropyrimido[5,4-c]isoquinoline
• CAS: 1421504-01-9
• 化学式: C₁₁H₆ClN₃
• 分子量: 215.642
• InChiKey: OSMZYPQKDRIBSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-5,6-dihydropyrimido[5,4-c]isoquinoline 在 氧气 作用下， 以 水 、 乙腈 为溶剂， 反应 5.0h， 以214 mg的产率得到4-chloropyrimido[5,4-c]isoquinoline
  参考文献：
  名称：

  Synthesis of Phenanthridine Derivatives by Microwave-Mediated Cyclization of o-Furyl(allylamino)arenes

  摘要：

  A novel and efficient synthesis of phenanthridines and aza analogues is reported. The key step is a microwave-mediated intramolecular Diels-Alder cyclization of o-furyl(allylamino)arenes. In the presence of a catalytic amount of acid, the DA-adduct reacts further to give the dihydrophenanthridines, which easily can be oxidized to fully aromatic compounds by air in the presence of UV light or by DDQ.

  DOI：

  10.1021/jo3027033

文献信息

• Biogenic synthesis of Pd-Fe@LLR nanocomposites as magnetically recyclable catalysts for C C and C N bond formation
  作者：Neetu Yaduvanshi、Sanjana Tewari、Shivangi Jaiswal、Meenu Devi、Shruti Shukla、Jaya Dwivedi、Swapnil Sharma

  DOI：10.1016/j.inoche.2023.111927

  日期：2024.3

  Pd-Fe@LLR was characterized using various techniques viz. UV, IR FE-SEM, XRD and VSM. Further Pd-Fe@LLR was utilized as catalyst for cross‐coupling reaction to afford tricyclic nitrogen containing heterocyclic scaffolds. Of note, the developed Pd-Fe@LLR catalyst demonstrated impressive activity towards CC and CN coupling reactions. In addition, the catalyst was magnetically recovered and reused for nine cycles

  本报告涉及采用绿色和可持续路线，使用枇杷叶提取物开发异质钯铁纳米复合材料（Pd-Fe@LLR NC）。开发的 Pd-Fe@LLR 使用各种技术进行了表征，即。紫外、红外 FE-SEM、XRD 和 VSM。此外，Pd-Fe@LLR 被用作交叉偶联反应的催化剂，以提供三环含氮杂环支架。值得注意的是，开发的 Pd-Fe@LLR 催化剂对 C C 和 C N 偶联反应表现出令人印象深刻的活性。此外，催化剂被磁力回收并重复使用九个循环，催化活性略有下降。
• Synthesis of Phenanthridine Derivatives by Microwave-Mediated Cyclization of <i>o</i>-Furyl(allylamino)arenes
  作者：Matthew Lovell Read、Lise-Lotte Gundersen

  DOI：10.1021/jo3027033

  日期：2013.2.1

  A novel and efficient synthesis of phenanthridines and aza analogues is reported. The key step is a microwave-mediated intramolecular Diels-Alder cyclization of o-furyl(allylamino)arenes. In the presence of a catalytic amount of acid, the DA-adduct reacts further to give the dihydrophenanthridines, which easily can be oxidized to fully aromatic compounds by air in the presence of UV light or by DDQ.