8-Bromo-6-hydroxy-6-methyl-indolo[2,1-b]quinazolin-12-one | 1421232-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-Bromo-6-hydroxy-6-methyl-indolo[2,1-b]quinazolin-12-one
• 英文别名: 8-bromo-6-hydroxy-6-methylindolo[2,1-b]quinazolin-12-one
• CAS: 1421232-22-5
• 化学式: C₁₆H₁₁BrN₂O₂
• 分子量: 343.18
• InChiKey: GKAXKZQFSNBZSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基溴化镁 、 8-bromoindolo[2,1-b]quinazoline-6,12-dione 以 四氢呋喃 为溶剂， 反应 3.0h， 以53%的产率得到8-Bromo-6-hydroxy-6-methyl-indolo[2,1-b]quinazolin-12-one
  参考文献：
  名称：

  Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position

  摘要：

  A panel of derivatives of the natural product tryptanthrin was synthesized and screened for its in vitro activity against the intracellular parasite Toxoplasma gondii. We concentrated on the modification of the 6-keto group of tryptanthrin and prepared a series of oximes, hydrazones and alcohols based on tryptanthrin. We evaluated parasite growth inhibition and host cell cytotoxicity. Our results indicate that in particular alcohol analogs are promising candidates for further investigation. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.12.024

文献信息

• Tryptanthrin derivatives as Toxoplasma gondii inhibitors—structure–activity-relationship of the 6-position
  作者：Bogdana Krivogorsky、Amber C. Nelson、Kelsi A. Douglas、Peter Grundt

  DOI：10.1016/j.bmcl.2012.12.024

  日期：2013.2

  A panel of derivatives of the natural product tryptanthrin was synthesized and screened for its in vitro activity against the intracellular parasite Toxoplasma gondii. We concentrated on the modification of the 6-keto group of tryptanthrin and prepared a series of oximes, hydrazones and alcohols based on tryptanthrin. We evaluated parasite growth inhibition and host cell cytotoxicity. Our results indicate that in particular alcohol analogs are promising candidates for further investigation. (C) 2012 Elsevier Ltd. All rights reserved.