3-(6-Ethoxybenzo[d]thiazol-2-yl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one (18) | 1421349-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 3-(6-Ethoxybenzo[d]thiazol-2-yl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one (18)
• 英文别名: 2-(2-chloro-6-fluorophenyl)-3-(6-ethoxy-1,3-benzothiazol-2-yl)-1,3-thiazolidin-4-one
• CAS: 1421349-88-3
• 化学式: C₁₈H₁₄ClFN₂O₂S₂
• 分子量: 408.905
• InChiKey: BUUVCGOFXZJKRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-6-乙氧基苯并噻唑 、 2-氯-6-氟-苯甲醛 、 巯基乙酸 生成 3-(6-Ethoxybenzo[d]thiazol-2-yl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one (18)
  参考文献：
  名称：

  Synthesis and HIV-1 RT inhibitory action of novel (4/6-substituted benzo[d]thiazol -2-yl)thiazolidin-4-ones. Divergence from the non-competitive inhibition mechanism

  摘要：

  Reverse transcriptase (RT) inhibitors play a major role in the therapy of human immunodeficiency virus type 1 (HIV-1) infection. Although, many compounds are already used as anti-HIV drugs, research on development of novel inhibitors continues, since drug resistant strains appear because of prolonged therapy. In this paper, we present the synthesis and evaluation of HIV-1 RT inhibitory action of eighteen novel (4/6-halogen/MeO/EtO-substituted benzo[d]thiazol-2-yl)thiazolidin-4-ones. The two more active compounds (IC50:0.04 mu M and 0.25 mu M) exhibited better inhibitory action than the reference compound, nevirapine. Docking analysis supports a stable binding of the most active derivative to the allosteric centre of RT. Kinetic analysis of two of the most active compounds indicate an uncompetitive inhibition mode. This is a desired characteristic, since mutations that affect activity of traditional non-competitive NNRTIs may not affect activity of compounds of this series. Interestingly, the less active derivatives (IC50 > 40 mu M) exhibit a competitive mode of action.

  DOI：

  10.3109/14756366.2011.636362

文献信息

• Nucleic acid sequencing methods and systems
  申请人：Omniome, Inc.

  公开号：US10077470B2

  公开（公告）日：2018-09-18

  The present disclosure provides compositions, methods and systems for sequencing a template nucleic acid using a polymerase based, nucleic acid binding reaction involving examination of the interaction between a polymerase and template nucleic acid in the presence of one or more unlabeled nucleotides. The methods rely, in part, on identifying a base of a template nucleic acid during nucleic acid synthesis by controlling the sequencing reaction conditions. Template nucleic acid bases may be identified during an examination step followed by an optional incorporation step.

  本公开提供了使用基于聚合酶的核酸结合反应对模板核酸进行测序的组合物、方法和系统，该反应涉及在存在一种或多种未标记核苷酸的情况下检查聚合酶与模板核酸之间的相互作用。这些方法部分依赖于在核酸合成过程中通过控制测序反应条件来识别模板核酸的碱基。模板核酸碱基可在检查步骤中识别，然后进行可选的结合步骤。
• Method and system for sequencing nucleic acids
  申请人：OMNIOME, INC.

  公开号：US10246744B2

  公开（公告）日：2019-04-02

  Provided are compositions, methods and systems for determining the sequence of a template nucleic acid using a polymerase-based, sequencing-by-binding procedure. An examination step involves monitoring the interaction between a polymerase and template nucleic acid in the presence of one or more nucleotides. Identity of the next correct nucleotide in the sequence is determined without incorporation of any nucleotide into the structure of the primer by formation of a phosphodiester bond. An optional incorporation step can be used after the examination step to extend the primer by one or more nucleotides, thereby incrementing the template nucleotides that can be examined in a subsequent examination step. The sequencing-by-binding procedure does not require the use of labeled nucleotides or polymerases, but optionally can employ these reagents.

  本文提供了利用基于聚合酶的结合测序程序确定模板核酸序列的组合物、方法和系统。检查步骤包括在存在一个或多个核苷酸的情况下监测聚合酶与模板核酸之间的相互作用。在序列中确定下一个正确核苷酸的身份时，无需通过形成磷酸二酯键将任何核苷酸掺入引物结构中。在检查步骤之后，可以使用一个可选的结合步骤，将引物延长一个或多个核苷酸，从而增加可在后续检查步骤中检查的模板核苷酸。结合测序程序不需要使用标记核苷酸或聚合酶，但也可选择使用这些试剂。
• NUCLEIC ACID SEQUENCING METHODS AND SYSTEMS
  申请人：Omniome, Inc.

  公开号：EP3325642A1

  公开（公告）日：2018-05-30
• NUCLEIC ACID SEQUENCING METHOD
  申请人：Omniome, Inc.

  公开号：EP3325642B1

  公开（公告）日：2020-05-27
• METHOD AND SYSTEM FOR SEQUENCING NUCLEIC ACIDS
  申请人：Omniome, Inc.

  公开号：EP3497236A1

  公开（公告）日：2019-06-19