2-amino-1-(pyridin-3-yl)ethanol dihydrochloride | 101012-01-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-1-(pyridin-3-yl)ethanol dihydrochloride
• 英文别名: 2-amino-1-[3]pyridyl-ethanol; dihydrochloride；2-Amino-1-[3]pyridyl-aethanol; Dihydrochlorid；2-Amino-1-(pyridin-3-yl)ethanol hydrochloride；2-amino-1-pyridin-3-ylethanol;hydrochloride
• CAS: 101012-01-5
• 化学式: C₇H₁₀N₂O*2ClH
• 分子量: 211.091
• InChiKey: PMVFSIPPTOOMTI-UHFFFAOYSA-N

物化性质

• 熔点：
  189.5-191 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2-amino-1-(pyridin-3-yl)ethanol dihydrochloride 在 氯化亚砜 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 Petroleum ether 为溶剂， 反应 18.0h， 生成 2-(1-((2-chloro-2-(pyridin-3-yl)ethyl)(2,4-dimethoxybenzyl)amino)cyclopropyl)acetonitrile
  参考文献：
  名称：

  [EN] STAT MODULATORS AND USES THEREOF
  [FR] MODULATEURS DE STAT ET LEURS UTILISATIONS

  摘要：

  Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6.

  公开号：

  WO2023192960A1

文献信息

• Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats
  作者：Yoshikazu Uto、Tsuneaki Ogata、Yohei Kiyotsuka、Yuko Ueno、Yuriko Miyazawa、Hitoshi Kurata、Tsuneo Deguchi、Nobuaki Watanabe、Masahiro Konishi、Ryo Okuyama、Nobuya Kurikawa、Toshiyuki Takagi、Satoko Wakimoto、Jun Ohsumi

  DOI：10.1016/j.bmcl.2009.10.101

  日期：2010.1

  Starting from a known piperazine-based SCD-1 inhibitor, we obtained more potent benzoylpiperidine analogs. Optimization of the structure of the benzoylpiperidine-based SCD-1 inhibitors resulted in the identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-yl-ethyl)amide (24) which showed strong inhibitory activity against both human and murine SCD-1. In addition, this compound exhibited good oral bioavailability and demonstrated plasma triglyceride lowering effects in Zucker fatty rats in a dose-dependent manner after a 7-day oral administration (qd). (C) 2009 Elsevier Ltd. All rights reserved.
• [EN] STAT MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE STAT ET LEURS UTILISATIONS
  申请人：[en]RECLUDIX PHARMA, INC.

  公开号：WO2023192960A1

  公开（公告）日：2023-10-05

  Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with STAT3 and/or STAT6.