6,7-Dimethoxy-2-(3-phenyl-propyl)-3,4-dihydro-2H-isoquinolin-1-one | 803705-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6,7-Dimethoxy-2-(3-phenyl-propyl)-3,4-dihydro-2H-isoquinolin-1-one
• 英文别名: 6,7-Dimethoxy-2-(3-phenylpropyl)-3,4-dihydroisoquinolin-1(2H)-one；6,7-dimethoxy-2-(3-phenylpropyl)-3,4-dihydroisoquinolin-1-one
• CAS: 803705-91-1
• 化学式: C₂₀H₂₃NO₃
• 分子量: 325.408
• InChiKey: GFLBLQDPOYGUKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯乙胺 、 对硝基苯基氯甲酸酯 、 alkaline earth salt of/the/ methylsulfuric acid 以61%的产率得到6,7-Dimethoxy-2-(3-phenyl-propyl)-3,4-dihydro-2H-isoquinolin-1-one
  参考文献：
  名称：

  Solid-phase synthesis of isoquinolinones using Bischler–Napieralski cyclization

  摘要：

  Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.059

文献信息

• Solid-phase synthesis of isoquinolinones using Bischler–Napieralski cyclization
  作者：Meei-Shiou Chern、Wen-Ren Li

  DOI：10.1016/j.tetlet.2004.09.059

  日期：2004.11

  Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen. (C) 2004 Elsevier Ltd. All rights reserved.