N-(2-aminooxyethyl)-N-(2-hydroxyethyl)-N,N-dimethyl-ammonium iodide | 1222450-63-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-aminooxyethyl)-N-(2-hydroxyethyl)-N,N-dimethyl-ammonium iodide
• 英文别名: N-(2-aminooxyethyl)-N-(2-hydroxyethyl)-N,N-dimethylammonium iodide；2-aminooxyethyl-(2-hydroxyethyl)-dimethylazanium;iodide
• CAS: 1222450-63-6
• 化学式: C₆H₁₇N₂O₂*I
• 分子量: 276.118
• InChiKey: RYCPXNCPVUEICY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.05
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 N-(2-aminooxyethyl)-N-(2-hydroxyethyl)-N,N-dimethyl-ammonium iodide
  参考文献：
  名称：

  Nucleophilic cationization reagents

  摘要：

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.094

文献信息

• NANOPARTICLES FOR DRUG DELIVERY
  申请人：Nantz Michael H.

  公开号：US20120302516A1

  公开（公告）日：2012-11-29

  The invention provides magnetic nanoparticles comprising a core, wherein the nanoparticles comprise at least one therapeutic agent linked to the core via a hydrazone linkage or via an oxime ether linkage, methods for making said nanoparticles, and methods for using said nanoparticles.

  该发明提供了磁性纳米颗粒，包括一个核心，其中纳米颗粒通过肼酰肼键或肟醚键与至少一种治疗剂连接，制备该纳米颗粒的方法以及使用该纳米颗粒的方法。
• [EN] NANOPARTICLES FOR DRUG DELIVERY<br/>[FR] NANOPARTICULES POUR L'ADMINISTRATION DE MÉDICAMENTS
  申请人：UNIV LOUISVILLE RES FOUND

  公开号：WO2011049972A1

  公开（公告）日：2011-04-28

  The invention provides magnetic nanoparticles comprising a core, wherein the nanoparticles comprise at least one therapeutic agent linked to the core via a hydrazone linkage or via an oxime ether linkage, methods for making said nanoparticles, and methods for using said nanoparticles.
• Nucleophilic cationization reagents
  作者：Souvik Biswas、Xuan Huang、Wesley R. Badger、Michael H. Nantz

  DOI：10.1016/j.tetlet.2010.01.094

  日期：2010.3

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.