3-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)propan-1-ol | 89151-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)propan-1-ol
• 英文别名: 3-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]propan-1-ol
• CAS: 89151-37-1
• 化学式: C₁₈H₂₅N₃O₃
• 分子量: 331.415
• InChiKey: MRRWKFFNFDGTDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  67.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] QUINAZOLINE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS<br/>[FR] DÉRIVÉS DE QUINAZOLINE UTILISÉS EN TANT QU'INHIBITEURS D'ECTONUCLÉOTIDE PYROPHOSPHATASE/PHOSPHODIESTÉRASE 1
  申请人：RIBOSCIENCE LLC

  公开号：WO2020140001A1

  公开（公告）日：2020-07-02

  The present disclosure provides certain quinazoline compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本公开提供了一些抑制细胞外核苷酸焦磷酸酶/磷酸二酯酶1（ENPP1）酶活性的喹唑啉化合物，因此对于治疗至少部分受ENPP1调节的疾病和病况是有用的。还提供了含有这些化合物的药物组合物以及制备这些化合物的方法。
• Quinazoline cardiac stimulants
  申请人：Pfizer Limited

  公开号：EP0135318A1

  公开（公告）日：1985-03-27

  Substituted-4-piperidino-quinazolines of the formula: are claimed as phosphodiesterase inhibitors and cardiac stimulants, useful in the treatment of heart failure, in which X is an alkylene group of the formula -CHR.CH2-, where R is H, CH3 or C2H5, and Y is an isothiazolidine-1,1-dioxide, tetrahydrothiazine-1,1-dioxide, 1,2,5-thiadiazolidine-1,1-dioxide, 1,2,6-thiadiazine-1,1-dioxide or tetrahydrothiadiazine-1.1-dioxide group linked to X by a ring nitrogen atom and optionally alkyl-substituted, and in which either the piperidine ring is further substituted with a hydroxy group in the 3- or 4- position orthe carbon atom of X attached to the piperidine ring is further substituted with a hydroxy group. If the piperidine ring is substituted with a hydroxy group in the 3-position then it may also be substituted in the same position with an alkyl group.

  式中的取代-4-哌啶基喹唑类： 其中X是式-CHR.CH2-的亚烷基，其中R是H、CH3或C2H5，Y是异噻唑烷-1,1-二氧化物、四氢噻嗪-1,1-二氧化物、1,2,5-噻二唑烷-1,1-二氧化物、1,2,6-噻二唑烷-1,1-二氧化物或四氢噻二唑烷-1.1-二氧化物或四氢噻二嗪-1.1-二氧化物，其中哌啶环在3-或4-位进一步被羟基取代，或连接到哌啶环上的X的碳原子进一步被羟基取代。如果哌啶环在 3 位被羟基取代，那么它也可以在同一位置被烷基取代。
• QUINAZOLINE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS
  申请人：Riboscience LLC

  公开号：EP3902787A1

  公开（公告）日：2021-11-03