7-But-2-ynyl-8-[3-(1,3-dioxoisoindol-2-yl)piperidin-1-yl]-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-But-2-ynyl-8-[3-(1,3-dioxoisoindol-2-yl)piperidin-1-yl]-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
• 化学式: C₃₃H₃₀N₈O₄
• 分子量: 602.6
• InChiKey: OXVXJPINFRNEPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  45
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  125
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] IMPROVED PROCESS FOR PREPARATION OF PURE LINAGLIPTIN<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE LINAGLIPTINE PURE
  申请人：REDDYS LAB LTD DR

  公开号：WO2013098775A1

  公开（公告）日：2013-07-04

  The present application provides a process for preparation of Linagliptin reacting (R)-piperidine-3-amine of Formula II or an acid addition salt thereof with 1-[(4-methyl- quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine of Formula III in the presence of a suitable base in an inert organic solvent.

  本申请提供了一种制备利那格列汀的方法，该方法是在惰性有机溶剂中，将II式的(R)-吡啶-3-胺或其酸盐与III式的1-[(4-甲基喹唑啉-2-基)甲基]-3-甲基-7-(2-丁炔基)-8-溴黄嘌呤在适当碱的存在下反应。
• METHOD FOR PREPARING AN IMPORTANT INTERMEDIATE OF LINAGLIPTIN
  申请人：2Y-CHEM, LTD.

  公开号：US20150274728A1

  公开（公告）日：2015-10-01

  The present invention discloses an improved process for preparing an important intermediate of linagliptin. In particular, disclosed are a process for preparing a compound V which is an important intermediate of linagliptin and has the structure V, and an industrial process of preparing linagliptin having excellent chemical and optical purities, which is an inhibitor of dipeptidyl peptidase-4 (DPP-IV), from the compound V. The process employs a phase-transfer catalyst, is high in yield, easy and simple to handle, environmentally friendly, suitable for industrial mass production, and can be implemented by a “one-pot process”.

  本发明公开了一种改进的制备利那格列汀重要中间体的工艺。具体公开了一种制备化合物V的工艺，该化合物V是利那格列汀的重要中间体，具有结构V，并且从化合物V中制备出具有优异化学和光学纯度的利那格列汀的工业工艺，利那格列汀是二肽基肽酶-4（DPP-IV）的抑制剂。该工艺采用相转移催化剂，产率高，易于操作和简单处理，环保，适合工业大规模生产，并且可以通过“一锅法”实施。
• PROCESS FOR PREPARATION OF PURE LINAGLIPTIN
  申请人：DR. REDDY'S LABORATORIES LIMITED

  公开号：US20140357863A1

  公开（公告）日：2014-12-04

  The present application provides a process for preparation of Linagliptin reacting (R)-piperidine-3-amine of Formula II or an acid addition salt thereof with 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine of Formula III in the presence of a suitable base in an inert organic solvent.

  本申请提供了一种制备林格列汀的方法，其中在惰性有机溶剂中，在适当的碱的存在下，将式II的(R)-哌啶-3-胺或其酸加成盐与式III的1-[(4-甲基-喹唑啉-2-基)甲基]-3-甲基-7-(2-丁炔-1-基)-8-溴黄嘌呤反应。
• VERFAHREN ZUR HERSTELLUNG CHIRALER 8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINE
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3029040A1

  公开（公告）日：2016-06-08

  Die Erfindung betrifft ein verbessertes Verfahren zur Herstellung enantiomerenreiner 8-(3-Amino-piperidin-1-yl)-xanthine.

  本发明涉及一种制备对映体纯度为 8-(3-氨基-1-哌啶基)-黄嘌呤的改进工艺。
• Verfahren zur Herstellung chiraler 8-(3-amino-piperidin-1yl)-Xanthine
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：EP2287164B9

  公开（公告）日：2014-06-11