ethyl 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate trifluoroacetate | 209339-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate trifluoroacetate
• 英文别名: ethyl 7-[6a-(aminomethyl)-3,3a,4,6-tetrahydro-2H-furo[2,3-c]pyrrol-5-yl]-1-cyclopropyl-8-fluoro-4-oxo-1,6-naphthyridine-3-carboxylate;2,2,2-trifluoroacetic acid
• CAS: 209339-43-5
• 化学式: C₂HF₃O₂*C₂₁H₂₅FN₄O₄
• 分子量: 530.476
• InChiKey: MTRKCSOXYQSFEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  135
• 氢给体数：
  2
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  ethyl 7-chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate 在 三氟乙酸 作用下， 生成 ethyl 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate trifluoroacetate
  参考文献：
  名称：

  Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith

  摘要：

  该发明涉及使用在位置7被1-氨基甲基-2-氧-7-氮代双环[3.3.0]辛-7-基取代的喹诺酮和萘啶酮羧酸衍生物，以及它们的盐用于治疗幽门螺杆菌感染和相关的胃十二指肠疾病。

  公开号：

  US06288081B1

文献信息

• Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolonecarboxylic acid and -naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and associated gastroduodenal disorders
  申请人：——

  公开号：US20010036941A1

  公开（公告）日：2001-11-01

  The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aninomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl radical, and of their salts for the therapy of Helicobacter pylori infections and associated gastroduodenal disorders.

  本发明涉及使用在第7位被1-氨甲基-2-氧杂-7-氮杂双环[3.3.0]辛-7-基基团取代的喹诺酮和萘啶酮羧酸衍生物及其盐，用于治疗幽门螺杆菌感染和相关的胃十二指肠疾病。
• US6288081B1
  申请人：——

  公开号：US6288081B1

  公开（公告）日：2001-09-11
• Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith
  申请人：Bayer Aktiengesellschaft

  公开号：US06288081B1

  公开（公告）日：2001-09-11

  The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl radical, and of their salts for the therapy of Helicobacter pylori infections and associated gastroduodenal disorders.

  该发明涉及使用在位置7被1-氨基甲基-2-氧-7-氮代双环[3.3.0]辛-7-基取代的喹诺酮和萘啶酮羧酸衍生物，以及它们的盐用于治疗幽门螺杆菌感染和相关的胃十二指肠疾病。