1-(Imidazo[1,2-a]pyrimidin-3-yl)ethanol | 453548-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]嘧啶
• 英文名称: 1-(Imidazo[1,2-a]pyrimidin-3-yl)ethanol
• 英文别名: 1-imidazo[1,2-a]pyrimidin-3-ylethanol
• CAS: 453548-58-8
• 化学式: C₈H₉N₃O
• 分子量: 163.18
• InChiKey: YOWJORGUWPKADL-UHFFFAOYSA-N

物化性质

• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION<br/>[FR] DERIVES DE LA PYRIMIDINE POUR INHIBER LA PROLIFERATION CELLULAIRE
  申请人：ASTRAZENECA AB

  公开号：WO2002066481A1

  公开（公告）日：2002-08-29

  Compounds of the formula (I): wherein Ring A, R?1, R3, R4¿, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-quest-blooded animal, such as man.

  公式（I）的化合物：其中环A，R？1，R3，R4¿，p，q和n如定义所述，并描述了药学上可接受的盐和体内可水解酯。还描述了它们的制备过程及其用作药物，特别是用作产生细胞周期抑制（抗细胞增殖）作用的药物，适用于温血动物，如人。
• Pyrimidine derivatives for inhibition of cell proliferation
  申请人：——

  公开号：US20040097506A1

  公开（公告）日：2004-05-20

  Compounds of the formula (I): wherein Ring A, R 1 , R 3 , R 4 , p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-quest-blooded animal, such as man. 1

  公式（I）的化合物：其中环A，R1，R3，R4，p，q和n的定义如内部所述，并描述了其药物可接受的盐和体内可水解酯。还描述了它们的制备过程以及它们作为药物的用途，特别是作为药物在温血动物（如人）中产生细胞周期抑制（抗细胞增殖）效果的药物。1
• PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION
  申请人：AstraZeneca AB

  公开号：EP1362050A1

  公开（公告）日：2003-11-19
• US6844341B2
  申请人：——

  公开号：US6844341B2

  公开（公告）日：2005-01-18