9-(7-heptanoylamino-1,8-naphthyridin-2-ylcarbamoyl)nonanoic acid 4-vinylbenzyl ester | 853684-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 9-(7-heptanoylamino-1,8-naphthyridin-2-ylcarbamoyl)nonanoic acid 4-vinylbenzyl ester
• 英文别名: (4-Ethenylphenyl)methyl 10-[[7-(heptanoylamino)-1,8-naphthyridin-2-yl]amino]-10-oxodecanoate
• CAS: 853684-80-7
• 化学式: C₃₄H₄₄N₄O₄
• 分子量: 572.748
• InChiKey: AJGOMOYEWPESPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  42
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  heptanoic acid (7-amino-[1,8]naphthyridin-2-yl)amide 、 decanedioic acid mono-(4-vinyl-benzyl) ester 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以94%的产率得到9-(7-heptanoylamino-1,8-naphthyridin-2-ylcarbamoyl)nonanoic acid 4-vinylbenzyl ester
  参考文献：
  名称：

  Formation of a Miscible Supramolecular Polymer Blend through Self-Assembly Mediated by a Quadruply Hydrogen-Bonded Heterocomplex

  摘要：

  A supramolecular network polymer consisting of a pair of immiscible polymers, poly( butyl)methacrylate ( PBMA) and polystyrene ( PS), is described. A urea of guanosine ( 1, UG) and 2,7-diamido1,8-naphthyridine ( 2, DAN), which form an exceptionally strong quadruply hydrogen-bonding complex, are displayed at 1-10 mol % along the main backbone of PBMA and PS, respectively. H-1 NMR studies show heterocomplexation between UG and DAN exclusively. This high-fidelity, high- affinity supramolecular connection of two different polymer coils at the molecular level produces a polymer blend. Blends containing different weight ratios of the polymers and mole percent of the recognition units were characterized by AFM and DSC experiments with no isolated domains observed and a single glass-transition temperature ( T-g). The T-g is tunable by varying the weight ratio of the polymers in the blend. In addition, viscosity measurements, size-exclusion chromatography ( SEC), and dynamic light-scattering ( DLS) studies demonstrate the formation of a supramolecular network structure.

  DOI：

  10.1021/ja0631854