1-Formyl-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene | 142065-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 1-Formyl-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene
• CAS: 142065-60-9
• 化学式: C₁₉H₂₆O₂Si
• 分子量: 314.5
• InChiKey: OIGWEZJEBWLFKX-ZCKJFHRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.59
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-Formyl-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.33h， 生成 1-(Acetoxymethyl)-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene
  参考文献：
  名称：

  A synthesis of various substituted naphthalenones by additions to naphthyloxazolines

  摘要：

  A series of synthetic manipulations on the naphthalene nucleus, containing a 1-(2-oxazolinyl) moiety, is described. Nucleophilic additions afford both regio- and stereoselective products in the 1- and 4-positions. The latter is oxidatively transformed in the 4-keto system 4 which can undergo various substitutions as well as carbonyl transpositions.

  DOI：

  10.1021/jo00041a030
• 作为产物：
  描述：

  1-(5,5-Dimethyl-2-oxazolinyl)-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene 生成 1-Formyl-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene
  参考文献：
  名称：

  A synthesis of various substituted naphthalenones by additions to naphthyloxazolines

  摘要：

  A series of synthetic manipulations on the naphthalene nucleus, containing a 1-(2-oxazolinyl) moiety, is described. Nucleophilic additions afford both regio- and stereoselective products in the 1- and 4-positions. The latter is oxidatively transformed in the 4-keto system 4 which can undergo various substitutions as well as carbonyl transpositions.

  DOI：

  10.1021/jo00041a030