[(2R,3S)-3-(2-ethoxyphenoxy)-2,3-dihydro-1-benzofuran-2-yl]methanol | 1033010-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: [(2R,3S)-3-(2-ethoxyphenoxy)-2,3-dihydro-1-benzofuran-2-yl]methanol
• CAS: 1033010-13-7
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.328
• InChiKey: SQBKJIODKDNDMU-SJORKVTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DIHYDROBENZOFURANYL DERIVATIVES AND METHODS OF THEIR USE
  申请人：Zhang Puwen

  公开号：US20080153873A1

  公开（公告）日：2008-06-26

  The present invention is directed to dihydrobenzofuranyl derivatives of formula I: or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorder, cognitive disorder, diabetic neuropathy, pain, and other diseases or disorders.

  本发明涉及具有以下结构的二氢苯并呋喃基衍生物：或其药用盐，这些衍生物是单胺再摄取抑制剂，含有这些衍生物的组合物，以及它们用于预防和治疗条件的方法，包括但不限于血管运动症状性功能障碍、胃肠道紊乱和泌尿系统紊乱、抑郁症、内源性行为障碍、认知障碍、糖尿病性神经病变、疼痛和其他疾病或障碍。
• [EN] DIHYDROBENZOFURANYL DERIVATIVES AND METHODS OF THEIR USE<br/>[FR] DÉRIVÉS DIHYDROBENZOFURANYLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：WYETH CORP

  公开号：WO2008073943A1

  公开（公告）日：2008-06-19

  [EN] The present invention is directed to dihydrobenzofuranyl derivatives of formula (I): or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorder, cognitive disorder, diabetic neuropathy, pain, and Other diseases or disorders.
  [FR] La présente invention concerne des dérivés dihydrobenzofuranyles de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, qui sont des inhibiteurs de recaptage des monoamines, des compositions contenant ces dérivés, et leurs procédés d'utilisation pour la prévention et le traitement de conditions comprenant, entre autres, les symptômes vasomoteurs, de dysfonctionnement sexuel, les troubles gastro-intestinaux, le trouble génito-urinaire, les troubles dépressifs, le trouble du comportement endogène, le trouble cognitif, la neuropathie diabétique, et d'autres maladies ou troubles.