(5R)-5-amino-5,6,7,8-tetrahydronaphthalen-1-ol | 1228559-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (5R)-5-amino-5,6,7,8-tetrahydronaphthalen-1-ol
• CAS: 1228559-62-3
• 化学式: C₁₀H₁₃NO
• mdl: MFCD06761961
• 分子量: 163.22
• InChiKey: JGBIMURCUPHILK-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] DIMERIC SMAC MIMETICS<br/>[FR] MIMÉTIQUES DIMÈRES DE SMAC
  申请人：JOYANT PHARMACEUTICALS INC

  公开号：WO2011059763A2

  公开（公告）日：2011-05-19

  The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.