Uracil, 1-arabinosyl-5-iodo- | 4334-76-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Uracil, 1-arabinosyl-5-iodo-
• 英文别名: 1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
• CAS: 4334-76-3
• 化学式: C₉H₁₁IN₂O₆
• 分子量: 370.1
• InChiKey: RKSLVDIXBGWPIS-KQTDWGMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Anti-HBV pyrimidine nucleoside
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0461815A1

  公开（公告）日：1991-12-18

  This invention relates to 1-(β-D-Arabinofuranosyl)5-prop-1-ynyluracil and pharmaceutically acceptable derivatives thereof for use in the treatment of hepatitis viral infections, particularly hepatitis B viral infections.

  本发明涉及1-(β-D-阿拉伯呋喃糖基)5-丙炔基尿嘧啶及其药学上可接受的衍生物，用于治疗病毒性肝炎，特别是乙型病毒性肝炎。
• IMAGING INFECTION WITH COMPOUNDS THAT BIND TO THYMIDINE KINASE
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：EP1768704A2

  公开（公告）日：2007-04-04
• USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS
  申请人：Virginia Commonwealth University

  公开号：EP3003022A1

  公开（公告）日：2016-04-13
• MDA-9/SYNTENIN PROMOTER TO IMAGE AND TREAT METASTATIC CANCER CELLS
  申请人：Virginia Commonwealth University

  公开号：EP3004872A1

  公开（公告）日：2016-04-13
• [EN] IMAGING INFECTION WITH COMPOUNDS THAT BIND TO THYMIDINE KINASE<br/>[FR] VISUALISATION D'UNE INFECTION AVEC DES COMPOSES SE LIANT A LA THYMIDINE KINASE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2006002142A2

  公开（公告）日：2006-01-05

  The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.