2-benzyloctahydro-1H-isoindol-4-amine | 217464-22-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-benzyloctahydro-1H-isoindol-4-amine
• 英文别名: 2-benzyl-1,3,3a,4,5,6,7,7a-octahydroisoindol-4-amine
• CAS: 217464-22-7
• 化学式: C₁₅H₂₂N₂
• 分子量: 230.35
• InChiKey: DEDUBZVXFIONOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

文献信息

• 2-OXOIMIDAZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0990653A1

  公开（公告）日：2000-04-05

  The present invention relates to a compound represented by Formula [I] [wherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R1 represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R 2 represents a hydrogen atom or a lower alkyl group], a salt or ester thereof, a production process for the same, and an analgesic, a reliever against tolerance to a narcotic analgesic represented by morphine, a reliever against dependence on a narcotic analgesic represented by morphine, an analgesic enhancer, an antiobestic, a drug for ameliorating brain function, a remedy for schizophrenia, a remedy for Parkinsonism, a remedy for chorea, an antidepressant, a remedy for diabetes insipidus, a remedy for polyuria, or a remedy for hypotension, comprising an effective ingredient of the same.

  本发明涉及一种由式[I]表示的化合物 其中 代表芳香族碳环或杂环，可以有取代基； Cy 代表具有 3 至 20 个碳原子的单环、双环或三环脂族碳环基团，可以有取代基； 代表具有 3 至 14 个碳原子的单环或双环脂族含氮杂环基团，该基团可具有取代基；R1 代表氢原子、低级烯基、低级炔基、环(低级烷基)基团、氨基、低级烷基氨基、二(低级烷基)氨基、羟基、低级烷氧基、羧基、低级烷氧羰基、氨基甲酰基、低级烷基氨基甲酰基或二(低级烷基)氨基甲酰基，或可带有取代基的低级烷基；以及 R 2 代表氢原子或低级烷基]，其盐或酯，其生产工艺，以及一种镇痛剂、一种防止对以吗啡为代表的麻醉性镇痛剂产生耐受性的缓解剂、一种防止对以吗啡为代表的麻醉性镇痛剂产生依赖性的缓解剂、一种镇痛增强剂、一种抗抑郁剂、一种改善脑功能的药物、一种治疗精神分裂症的药物、一种治疗帕金森病的药物、一种治疗舞蹈症的药物、一种抗抑郁剂、一种治疗糖尿病的药物、一种治疗多尿症的药物或一种治疗低血压的药物，其中包括一种有效成分。
• US6258825B1
  申请人：——

  公开号：US6258825B1

  公开（公告）日：2001-07-10
• [EN] NEW COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：SANOFI SYNTHELABO

  公开号：WO2005021536A2

  公开（公告）日：2005-03-10

  The invention relates to new compounds of the general formula (I), which are strong DPP-IV enzyme inhibitors.