2',3'-Isopropyliden-3,5'-inosincyclonucleosid | 21017-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2',3'-Isopropyliden-3,5'-inosincyclonucleosid
• 英文别名: 2',3'-O-Isopropyliden-3,5'-cyclo-inosin；2',3'-O-Isopropyliden-3.5'-inosin-cyclonucleosid；3,5'-Anhydro-2',3'-O-isopropylideninosin；O^2'_,O3'-isopropylidene-3,5'-cyclo-5'-deoxy-inosine；(8R)-10,10-dimethyl-(8at,11at)-8,8a,11a,12-tetrahydro-7H-8r,12c-epioxido-[1,3]dioxolo[4',5':5,6][1,3]diazocino[1,2,3-cd]purin-3-one
• CAS: 21017-06-1
• 化学式: C₁₃H₁₄N₄O₄
• 分子量: 290.279
• InChiKey: GFNBNMVZIOKTJX-WOUKDFQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.02
• 重原子数：
  21.0
• 可旋转键数：
  0.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  80.4
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  (4R)-6-formyl-2,2-dimethyl-(3at,11at)-3a,4,5,6,11,11a-hexahydro-4r,11c-epioxido-[1,3]dioxolo[4,5-f]imidazo[1,5-a][1,3]diazocine-7-carboxylic acid amide 生成 2',3'-Isopropyliden-3,5'-inosincyclonucleosid
  参考文献：
  名称：

  Reinvestigation of 3,5'-anhydro-2',3'-O-isopropylideneinosine

  摘要：

  DOI：

  10.1021/jo00941a051

文献信息

• Studies of Phosphorylation. II. Reaction of 2′, 3′-<i>O</i>-Isopropylideneinosine and -guanosine with Phosphoryl Chloride¹
  作者：Koji Kusashio、Masaharu Yoshikawa

  DOI：10.1246/bcsj.41.142

  日期：1968.1

  Several reactions accompanied by the phosphorylation of 2′, 3′-O-isopropylidene nucleosides with phosphoryl chloride in the absence of an organic solvent were investigated. When the reaction temperature exceeded 30°C, 2′, 3′-O-isopropylideneinosine gave 5′-chloro-5′-deoxy 2′, 3′-O-isopropylideneinosine and 5′-deoxy-2′, 3′-O-isopropylidene-3, 5′-cycloinosine. This cycloinosine, was then further subjected

  研究了在没有有机溶剂的情况下，伴随着 2', 3'-O-异亚丙基核苷与磷酰氯的磷酸化的几个反应。当反应温度超过 30°C 时，2', 3'-O-isopropylideneinosine 生成 5'-chloro-5'-deoxy 2', 3'-O-isopropylideneinosine 和 5'-deoxy-2', 3'-O -isopropylidene-3, 5'-cycloinosine。然后该环肌苷在嘧啶环中进一步快速裂解，得到 5-amino-4-carbamoyl-N5, 5'-cyclo-1-β-D-(5'-deoxy-2', 3'-O - 异亚丙基呋喃核糖基)-咪唑、5-氨基-4-氰基-N5、5'-环-1-β-D-(5'-脱氧-2'、3'-O-异亚丙基呋喃核糖基)-咪唑和N5-后者的甲酰基衍生物。在 2', 3'-O-异亚丙基鸟苷的情况下，观察到类似的 5'-位氯化和
• Halo sugar nucleosides. I. Iodination of the primary hydroxyl groups of nucleosides with methyltriphenoxyphosphonium iodide
  作者：Julien P. H. Verheyden、John G. Moffatt

  DOI：10.1021/jo00832a047

  日期：1970.7
• Purine Nucleosides. V. Preparation and Reactions of Some 9β-D-Ribofuranosyl-3,5'-purine Cyclonucleosides^1,2
  作者：Richard E. Holmes、Roland K. Robins

  DOI：10.1021/jo01047a050

  日期：1963.12