3-(4-methylphenethyl)-2-phenylquinazolin-4(3H)-one | 1391611-30-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(4-methylphenethyl)-2-phenylquinazolin-4(3H)-one
• CAS: 1391611-30-5
• 化学式: C₂₃H₂₀N₂O
• 分子量: 340.425
• InChiKey: SRJAPWARNAANMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  34.89
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  苯草灭 在 potassium carbonate 、 formamide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 3-(4-methylphenethyl)-2-phenylquinazolin-4(3H)-one 、 4-(4-methylphenethoxy)-2-phenylquinazoline
  参考文献：
  名称：

  Design, synthesis and biological evaluation of novel quinazoline derivatives as potential anti-cancer agents

  摘要：

  Twenty-two quinazoline derivatives have been synthesised and examined for their anti-tumour activity against three tumour cell lines, namely human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human hepatoma cell line (HepG2). Twelve of the tested compounds have shown promising anti-tumour activity with an IC50 range of 5.0-9.7 mu g/mL. Regarding the spectrum of activity, five compounds exhibited interesting anti-proliferative properties against the three tested cell lines comparable to the reference drug (dasatinib).

  DOI：

  10.3109/14756366.2011.601302