2-(6-hydroxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid hydrazide | 36705-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(6-hydroxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid hydrazide
• 英文别名: 2-(6-Hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazole-4-carbohydrazide
• CAS: 36705-74-5
• 化学式: C₁₁H₈N₄O₂S₂
• 分子量: 292.342
• InChiKey: ADFQXOMQMHVQNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  158
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  dehydroluciferin methyl ester 在 肼 作用下， 以 乙醇 为溶剂， 生成 2-(6-hydroxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid hydrazide
  参考文献：
  名称：

  Chemiluminescence of linear hydrazides

  摘要：

  DOI：

  10.1021/ja00764a044

文献信息

• Chemiluminescent and fluorescent substrate pads and uses thereof
  申请人：PIERCE BIOTECHNOLOGY, INC.

  公开号：US10722882B2

  公开（公告）日：2020-07-28

  The disclosure provides compositions, kits and methods comprising an absorbent pad comprising a fibrous material and a liquid formulation comprising a luminescent substrate for identifying and quantifying biomolecule analytes.

  本公开提供的组合物、试剂盒和方法包括由纤维材料组成的吸收垫和由发光基质组成的液体配方，用于识别和量化生物大分子分析物。
• Novel stabilized formulations for chemiluminescent assays
  申请人：——

  公开号：US20010046688A1

  公开（公告）日：2001-11-29

  A substrate having an extended shelf life for chemiluminescent detection and assaying is useful with enzyme-based probes as well as for immunoassays, DNA or RNA or protein detection and blotting. The substrate is a mixture of (a) a chemiluminescent compound, (b) an oxidant, (c) a stabilizer and (d) a buffer. The substrate may further include a chemiluminescent enhancer and a solubilizer. The substrate may be in an organic solvent or may be aqueous based.

  用于化学发光检测和化验的底物具有较长的保存期，可用于酶探针、免疫测定、DNA 或 RNA 或蛋白质检测和印迹。底物是由（a）化学发光化合物、（b）氧化剂、（c）稳定剂和（d）缓冲液组成的混合物。底物可进一步包括化学发光增强剂和增溶剂。基质可以是有机溶剂，也可以是水基。
• EP1254252A4
  申请人：——

  公开号：EP1254252A4

  公开（公告）日：2006-06-07
• CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF
  申请人：Pierce Biotechnology, Inc.

  公开号：EP3494396A1

  公开（公告）日：2019-06-12
• Stabilized two component system for chemiluminescent assay in immunodiagnostics
  申请人：Kalra Bhanu

  公开号：US20050272108A1

  公开（公告）日：2005-12-08

  The present invention provides stabilized chemiluminescent formulations for use in in vitro diagnostics, including competitive as well as sandwich-type immunological assays. The stabilized assay system may be composed of two components, where the first component may contain a chemiluminescent organic compound, an enhancer, a homogenizing agent, and a suitable buffer with formulations having a pH range from about 7.2 to about 12, and optionally a solubilizing agent. The chemiluminescent system of the present invention is useful in immunoenzymatic analytical procedures, such as immunometric, competitive binding and sandwich type assays. In such immunoassays employing the chemiluminescent system of the present invention, the detectable light signal shows a proportional decay with time in the test samples and standards, so that the decay of the light emitted does not effect the concentration of the analyte measured over the entire analyte measurement range of the immunoassay. This allows accurate measurement of analyte concentrations in a test sample over extended periods of time.