(4-hydroxy-phenylimino)-phenyl-acetonitrile | 2054-19-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (4-hydroxy-phenylimino)-phenyl-acetonitrile
• 英文别名: (4-Oxy-phenyl)-(μ-cyan-azo-methin)-phenyl；(4-Hydroxy-phenylimino)-phenyl-acetonitril；4-(α-Cyan-benzalamino)-phenol；<2-Phenyl-glyoxylsaeurenitril>-<4-hydroxy-phenylimin>；α--phenylacetonitril；α-Cyan-N-benzyliden-p-hydroxy-anilin；N-(4-hydroxyphenyl)benzenecarboximidoyl cyanide
• CAS: 2054-19-5
• 化学式: C₁₄H₁₀N₂O
• 分子量: 222.246
• InChiKey: GAVKVMJTNVJCOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.38
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium permanganate 、 丙酮 作用下， 生成 (4-hydroxy-phenylimino)-phenyl-acetonitrile
  参考文献：
  名称：

  LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE

  摘要：

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.

  DOI：

  10.1016/s0022-5347(05)67701-4

文献信息

• DE121974
  申请人：——

  公开号：——

  公开（公告）日：——