1,2-Dipalmitoyl-sn-glycero-3-ethylphosphocholine | 214599-00-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-Dipalmitoyl-sn-glycero-3-ethylphosphocholine
• 英文别名: 2-[[(2R)-2,3-di(hexadecanoyloxy)propoxy]-ethoxyphosphoryl]oxyethyl-trimethylazanium
• CAS: 214599-00-5
• 化学式: C42H85NO8P+
• 分子量: 763.1
• InChiKey: VBZSUWNESITEBV-KHBQWKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.4
• 重原子数：
  52
• 可旋转键数：
  42
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• COMPOSITIONS AND METHODS FOR DELIVERY OF DOUBLE-STRANDED RNA
  申请人：Cui Kunyuan

  公开号：US20070293449A1

  公开（公告）日：2007-12-20

  Pharmaceutical compositions and methods of use of a composition containing a double-stranded RNA (dsRNA), cationic lipids, non-cationic lipids, and lipophilic delivery-enhancing compounds.
• COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
  申请人：Cui Kunyuan

  公开号：US20070281900A1

  公开（公告）日：2007-12-06

  A composition of an interfering RNA comprising a double-stranded RNA (dsRNA) molecule having a double-stranded region of from about 15 to about 40 base pairs, a peptide having a hydrophobic region and a cationic region, and a non-cationic phospholipid, and uses thereof.
• [EN] LIPIDS CAPABLE OF CONFORMATIONAL CHANGE AND THEIR USE IN FORMULATIONS TO DELIVER THERAPEUTIC AGENTS TO CELLS<br/>[FR] LIPIDES POUVANT SUPPORTER UN CHANGEMENT CONFORMATIONNEL ET UTILISATION DE CES DERNIERS DANS DES FORMULATIONS AFIN D'APPORTER DES AGENTS THÉRAPEUTIQUES À DES CELLULES
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2013032643A2

  公开（公告）日：2013-03-07

  The invention provides lipid-based composition for use in the administration of therapeutic payloads to target cells or tissues in vivo. The lipid compounds of the invention include a peptide-based moiety which is induced to change its conformation upon entering a cell or intracellular compartment. The induced conformation change in the peptide-based moiety consequently triggers the efficient release of the payload from the lipid-based composition.