(3S)-N-{1-[(5-phenyl-1,3-dihydro-2H-isoindol-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine | 1373523-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (3S)-N-{1-[(5-phenyl-1,3-dihydro-2H-isoindol-2-yl)carbonyl]azetidin-3-yl}-1-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-3-amine
• 英文别名: [(3S)-3-[[1-(5-phenyl-1,3-dihydroisoindole-2-carbonyl)azetidin-3-yl]amino]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
• CAS: 1373523-26-2
• 化学式: C₂₆H₂₇N₅O₂S
• 分子量: 473.599
• InChiKey: SIJZFGQIBHLFQH-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  97
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
  申请人：Zhang Yue-Mei

  公开号：US20120101081A1

  公开（公告）日：2012-04-26

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R 1 , and R 2 are defined herein.

  揭示了用于治疗各种疾病、综合症、症状和紊乱的化合物、组合物和方法，包括疼痛。这些化合物及其对映体、顺反异构体和药用盐由以下式(I)所代表：其中Y、Z、R1和R2在此处定义。
• US8575363B2
  申请人：——

  公开号：US8575363B2

  公开（公告）日：2013-11-05
• US8748417B2
  申请人：——

  公开号：US8748417B2

  公开（公告）日：2014-06-10
• [EN] AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS<br/>[FR] AMINO-PYRROLIDINE-AZÉTIDINE DIAMIDES UTILISÉS COMME INHIBITEURS DE LA MONOACYLGLYCÉROL LIPASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012054721A1

  公开（公告）日：2012-04-26

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: (I) wherein Y, Z, and R1 and R2 are defined herein.