4-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)-N-(32-amino-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontyl)-benzamide | 1274810-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 4-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)-N-(32-amino-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontyl)-benzamide
• 英文别名: N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-4-[[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9-yl]methyl]benzamide
• CAS: 1274810-62-6
• 化学式: C₃₈H₆₃N₇O₁₄
• 分子量: 841.957
• InChiKey: PFLOLOSUKCUWPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  59
• 可旋转键数：
  39
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  250
• 氢给体数：
  4
• 氢受体数：
  18

文献信息

• [EN] IMMUNOTHERAPEUTIC TUMOR TREATMENT METHOD<br/>[FR] MÉTHODE DE TRAITEMENT DE TUMEUR IMMUNOTHÉRAPEUTIQUE
  申请人：NEKTAR THERAPEUTICS

  公开号：WO2018204528A1

  公开（公告）日：2018-11-08

  Provided is a method of administering to a patient having cancer: (a) a 4-1BB agonist; (b) an IL-2Rβ-activating amount of a long-acting, IL-2Rβ-selective agonist; and/or (c) a toll-like receptor agonist, as well as related compositions, kits and compositions.

  提供一种治疗癌症患者的方法：(a) 4-1BB激动剂；(b)长效、选择性激活IL-2Rβ的激动剂的IL-2Rβ激活剂量；和/或(c)类似于toll样受体的激动剂，以及相关的组合物、套装和组合物。
• MULTI-ARM POLYMER CONJUGATES OF TLR AGONIST COMPOUNDS AND RELATED IMMUNOTHERAPEUTIC TREATMENT METHODS
  申请人：Nektar Therapeutics

  公开号：EP3568162A1

  公开（公告）日：2019-11-20
• IMMUNOTHERAPEUTIC TUMOR TREATMENT METHOD
  申请人：Nektar Therapeutics

  公开号：EP3628010A1

  公开（公告）日：2020-04-01
• TREATMENT OF CONDITIONS BY TOLL-LIKE RECEPTOR MODULATORS
  申请人：Holldack Johanna

  公开号：US20120083473A1

  公开（公告）日：2012-04-05

  Provided herein are methods for treating certain conditions, including fibrosis, inflammatory, and autoimmune conditions, with conjugated compounds having Toll-like receptor modulatory activity.
• [EN] MULTI-ARM POLYMER CONJUGATES OF TLR AGONIST COMPOUNDS AND RELATED IMMUNOTHERAPEUTIC TREATMENT METHODS<br/>[FR] CONJUGUÉS POLYMÈRES À BRAS MULTIPLES DE COMPOSÉS AGONISTES DE TLR ET MÉTHODES DE TRAITEMENT IMMUNOTHÉRAPEUTIQUES ASSOCIÉES
  申请人：NEKTAR THERAPEUTICS

  公开号：WO2018132496A1

  公开（公告）日：2018-07-19

  Provided are multi-arm polymer conjugates of Toll-Like Receptor ("TLR") agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and -NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2Rβ-activating amount of a long-acting, IL-2Rβ-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.