3-((1R)-1-{4-[(t-butylamino)methyl]-2-methylphenyl}ethoxy)-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide | 886860-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-((1R)-1-{4-[(t-butylamino)methyl]-2-methylphenyl}ethoxy)-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide
• 英文别名: (R)-3-(1-(4-((tert-butylamino)methyl)-2-methylphenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide；3-[(1R)-1-[4-[(tert-butylamino)methyl]-2-methylphenyl]ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide
• CAS: 886860-58-8
• 化学式: C₂₆H₃₀N₄O₂S
• 分子量: 462.616
• InChiKey: JUIWNZRHTWSHBL-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL FUSED IMIDAZOLE DERIVATIVE
  申请人：MSD K.K.

  公开号：EP1813613B1

  公开（公告）日：2012-12-19
• Novel Fused Imidazole Derivative
  申请人：Sato Yoshiyuki

  公开号：US20080103136A1

  公开（公告）日：2008-05-01

  The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A 1 and A 2 , are each a nitrogen atom, and the like; X 2 , X 3 , X 4 , and X 5 are all carbon atoms, or alternatively any one of X 2 , X 3 , X 4 , and X 5 is a nitrogen atom and the rest are all carbon atoms; R 1 is a hydrogen atom, or the like; R 2 , R 3 , R 4 , and R 5 , are each a hydrogen atom, or the like; R 6 and R 6 ′, are each a hydrogen atom, and the like; R 7 is an aryl group and the like; and R 8 is an amino group or a hydroxy group, or a pharmaceutically acceptable salt or ester thereof.
• US8030327B2
  申请人：——

  公开号：US8030327B2

  公开（公告）日：2011-10-04