2-(4-{methyl[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoic acid | 1217896-11-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(4-{methyl[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoic acid
• 英文别名: 2-[4-[Methyl-[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino]phenyl]propanoic acid
• CAS: 1217896-11-1
• 化学式: C₁₄H₁₃F₃N₂O₂S
• 分子量: 330.331
• InChiKey: FQTRGPOTTZHVLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl 2-(4-{methyl[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoate 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以97%的产率得到2-(4-{methyl[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoic acid
  参考文献：
  名称：

  2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them

  摘要：

  本发明涉及(R,S) 2-芳基丙酸及其衍生物，它们的单对映体(S)，以及含有它们的药物组合物，用于预防和治疗由于在炎症部位过度招募多形核中性粒细胞（PMN白细胞）而导致的组织损伤。 本发明提供了用于治疗短暂性脑缺血、水疱性天疱疮、类风湿关节炎、特发性纤维化、肾小球肾炎以及缺血再灌注引起的损伤的化合物。

  公开号：

  EP2166006A1

文献信息

• 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them
  申请人：Allegretti Marcello

  公开号：US20110207785A1

  公开（公告）日：2011-08-25

  The present invention relates to (R,S) 2-aryl-propionic acids and derivatives, their single enantiomer (S) and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PIvTN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion. (Formula (I)

  本发明涉及(R,S) 2-芳基丙酸及其衍生物，它们的单对映体(S)，以及含有它们的制药组合物，用于预防和治疗由于在炎症部位极化中性粒细胞（PIvTN白细胞）的过度招募而导致的组织损伤。本发明提供了用于治疗短暂性脑缺血、天疱疮、类风湿性关节炎、特发性纤维化、肾小球肾炎以及缺血再灌注引起的损伤的化合物。（公式（I））
• 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Dompé S.p.A.

  公开号：EP2346841B1

  公开（公告）日：2015-01-14
• US8624036B2
  申请人：——

  公开号：US8624036B2

  公开（公告）日：2014-01-07
• [EN] 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] ACIDES 2-ARYL-PROPIONIQUES, LEURS DÉRIVÉS ET COMPOSITIONS PHARMACEUTIQUES EN CONTENANT
  申请人：DOMPE SPA

  公开号：WO2010031835A2

  公开（公告）日：2010-03-25

  The present invention relates to (R, S) 2-aryl-propionic acids and derivatives, their single enantiomer (S) and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion.
• 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
  申请人：Dompe' S.P.A.

  公开号：EP2166006A1

  公开（公告）日：2010-03-24

  The present invention relates to (R,S) 2-aryl-propionic acids and derivatives, their single enantiomer (S) and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pcmphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion.

  本发明涉及(R,S) 2-芳基丙酸及其衍生物，它们的单对映体(S)，以及含有它们的药物组合物，用于预防和治疗由于在炎症部位过度招募多形核中性粒细胞（PMN白细胞）而导致的组织损伤。 本发明提供了用于治疗短暂性脑缺血、水疱性天疱疮、类风湿关节炎、特发性纤维化、肾小球肾炎以及缺血再灌注引起的损伤的化合物。