Diphenyl-<2-((S)-1-phenyl-ethylamino)-ethyl>-phosphin | 87152-45-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Diphenyl-<2-((S)-1-phenyl-ethylamino)-ethyl>-phosphin
• 英文别名: (S)-2-(diphenylphosphaneyl)-N-(1-phenylethyl)ethan-1-amine；[2-(diphenylphosphino)ethyl]-(S)-1-phenylethylamine；Diphenyl-[2-((S)-1-phenyl-ethylamino)-ethyl]-phosphin；(1S)-N-(2-diphenylphosphanylethyl)-1-phenylethanamine
• CAS: 87152-45-2
• 化学式: C₂₂H₂₄NP
• 分子量: 333.413
• InChiKey: JZXVXENUGRCZAU-IBGZPJMESA-N

物化性质

• 沸点：
  175 °C(Press: 0.01 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  4.47
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  12.03
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  (1S)-N-[2-(benzyl-bromo-diphenyl-λ5-phosphanyl)ethyl]-1-phenylethanamine 以91%的产率得到
  参考文献：
  名称：

  HORNER, L.;DICHERHOF, K., PHOSPH. AND SULFUR, 1983, 15, N 3, 331-349

  摘要：

  DOI：

文献信息

• Using Catalysts To Make Catalysts: Titanium-Catalyzed Hydroamination To Access <i>P,N</i>-Ligands for Assembling Catalysts in One Pot
  作者：Han Hao、Thibault Bagnol、Mathieu Pucheault、Laurel L. Schafer

  DOI：10.1021/acs.orglett.0c04212

  日期：2021.3.19

  Using a diamido-bis(amidate) titanium precatalyst, the hydroamination of alkynylphosphines afforded phosphinoenamine products. After reduction, 2-aminophosphines are prepared in excellent yield and on gram scale. A broad variety of alkynylphosphines and primary amines with different electronic and steric features are tolerated in this sequential transformation, enabling the rapid assembly of a collection

  使用二酰胺基双（氨基甲酸酯）钛预催化剂，炔基膦的氢化胺化得到膦烯胺产物。还原后，以极好的收率和克级制备2-氨基膦。在这种顺序转换中，可以耐受具有不同电子和空间特征的各种炔基膦和伯胺，从而可以快速组装一系列配体。此外，中间体膦基烯胺可以直接用作配体，通过质子分解或盐复分解反应配位到过渡金属。这些转化导致易于使用的一锅法操作，以制备用于催化或小分子活化的金属P，N-配合物。
• Mixed donor aminophosphine oxide ligands in ruthenium-catalysed asymmetric transfer hydrogenation reactions
  作者：Mohammed S. Rahman、Marco Oliana、King Kuok (Mimi) Hii

  DOI：10.1016/j.tetasy.2004.05.001

  日期：2004.6

  A number of mixed-donor aminophosphine ligands have been prepared and their activity and selectivity in asymmetric transfer hvdrogenation reactions assessed. Enantioselectivities up to 93% and 80% were achieved for the reduction of acetophenone and propiophenone, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
• Enantioselektive Katalysen
  作者：Henri Brunner、Stephan Limmer

  DOI：10.1016/0022-328x(91)80171-f

  日期：1991.10

  The addition of the optically active amines (-)-1-phenylethylamine, (+)-1-phenylethylamine, and (+)-3-aminomethylpinane to diphenylvinylphosphine oxide or 1,1-bis(diphenylphosphino)ethene sulfide gives new PN compounds which were used as cocatalysts in the cross coupling of 1-phenylethyl Grignard with vinylbromide and in the hydrosilylation of acetophenone with diphenylsilane.
• Horner, Leopold; Dickerhof, Karlheinz, Phosphorus and Sulfur and the Related Elements, 1983, vol. 15, p. 331 - 350
  作者：Horner, Leopold、Dickerhof, Karlheinz

  DOI：——

  日期：——