(1-methylbenzimidazol-5-yl)methyl N-[5-(4-chloro-2-methoxyphenyl)-2-propan-2-ylpyrazol-3-yl]carbamate | 1354399-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-methylbenzimidazol-5-yl)methyl N-[5-(4-chloro-2-methoxyphenyl)-2-propan-2-ylpyrazol-3-yl]carbamate
• CAS: 1354399-39-5
• 化学式: C₂₃H₂₄ClN₅O₃
• 分子量: 453.928
• InChiKey: WPFDGKSKWJDDPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  83.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR
  申请人：Uchida Hiroshi

  公开号：US20130079306A1

  公开（公告）日：2013-03-28

  A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27 Kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

  提供了一种新型杂环化合物或其盐，用于选择性地抑制p27Kip1的降解。该化合物或其盐由以下式（1）表示：其中A代表烷基、环烷基、芳基或杂环基，基团A可能有取代基；环B代表5至8成员的单环杂环环或包含该单环杂环环的缩合环，环B可能有取代基；环C代表芳香环，环C可能有取代基；L代表包含3至5个原子的主链的连接物，所述原子选自碳原子、氮原子、氧原子和硫原子组成的群，其中主链中的至少一个原子是选自氮原子、氧原子和硫原子组成的杂原子，连接物L可能有取代基；n为0或1。
• HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR
  申请人：ASKA Pharmaceutical Co., Ltd.

  公开号：EP2594555A1

  公开（公告）日：2013-05-22

  A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

  本研究提供了一种新型杂环化合物或其盐，可用于选择性抑制 p27kip1 的降解。该化合物或其盐由下式（1）表示： 其中 A 代表烷基、环烷基、芳基或杂环基，该基团 A 可具有取代基；环 B 代表 5 至 8 元单环杂环或含有单环杂环的缩合环，该环 B 可具有取代基；环 C 代表芳香环，该环 C 可具有取代基；L 代表由主链组成的连接体，该主链具有 3 至 5 个原子，选自由碳原子、氮原子、氧原子和硫原子组成的组，其中主链中至少有一个原子是选自由氮原子、氧原子和硫原子组成的组的杂原子，连接体 L 可具有取代基；以及 n 为 0 或 1。
• US9200008B2
  申请人：——

  公开号：US9200008B2

  公开（公告）日：2015-12-01