(R)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide dihydrochloride | 173897-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide dihydrochloride
• 英文别名: (R)-(+)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide 2HCl；WF-536 Hydrochloride；4-[(1R)-1-aminoethyl]-N-pyridin-4-ylbenzamide;hydrochloride
• CAS: 173897-36-4
• 化学式: C₁₄H₁₅N₃O*2ClH
• 分子量: 314.214
• InChiKey: DVCLJVOQDUIPOT-HNCPQSOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide dihydrochloride 在 lithium hydroxide monohydrate 、 水 、 potassium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 84.0h， 生成 tert-butyl (R)-(20-hydroxy-3,6,9,12,15,18-hexaoxaicosyl)(1-(4-(pyridin-4-ylcarbamoyl)phenyl)ethyl)carbamate
  参考文献：
  名称：

  WO2024071371A1

  摘要：

  公开号：
• 作为产物：
  描述：

  methyl (R)-4-(1-((tert-butoxycarbonyl)amino)ethyl)benzoate 在 盐酸 、 lithium hydroxide monohydrate 、 水 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 52.0h， 生成 (R)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide dihydrochloride
  参考文献：
  名称：

  WO2024071371A1

  摘要：

  公开号：

文献信息

• INDUCTION OF PLURIPOTENT CELLS
  申请人：Lin Tongxiang

  公开号：US20120264218A1

  公开（公告）日：2012-10-18

  The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

  人类诱导多能干细胞（iPSCs）生成的方法动力学缓慢且效率低，限制了它们在生物医学应用中的实用性。在这里，我们描述了一种化学方法，可显著提高从人类成纤维细胞生成iPSC的效率（提高了200倍以上），并在治疗后七天内完成。这将为开发更安全、更高效、非病毒方法重新编程人类体细胞奠定基础。
• N-heterocyclic substituted benzamide derivatives with antihypertensive activity
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1195372A1

  公开（公告）日：2002-04-10

  Benzamide compounds of the formula wherein each symbol is as defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of this compound and a pharmaceutically acceptable additive, and therapeutic agents for hypertension, therapeutic agents for angina pectoris, therapeutic agent for asthma, therapeutic agents for renal and peripheral circulatory disturbances and inhibitor of cerebral vasospasm, which comprise this compound. The compound of the present invention has strong smooth muscle relaxing action, and shows hypotensive action and cerebral • coronary vasodilating action like conventional calcium antagonists, as well as long-lasting renal and peripheral circulation improving action. Unlike calcium antagonists, it permits oral administration to suppress vascular contraction caused by various agonists, and is useful as a strong and long-acting agent for prophylaxis and treatment of circulatory diseases in coronary, cerebral, renal and peripheral arteries, as a therapeutic agent for hypertension, angina pectoris, and renal and peripheral circulation disorder, an inhibitor of cerebral vasospasm and the like. Moreover, the compound of the present invention is useful as a therapeutic agent for asthma.

  苯甲酰胺化合物的化学式如规范中所定义的每个符号，其异构体和药学上可接受的酸盐。包括该化合物的治疗有效量和药学上可接受的添加剂的药物组合物，以及治疗高血压、心绞痛、哮喘、肾脏和外周循环障碍以及脑血管痉挛抑制剂的治疗剂，其中包括该化合物。本发明的化合物具有强大的平滑肌松弛作用，表现出类似于传统钙拮抗剂的降压作用和脑冠脉扩张作用，以及持久的肾脏和外周循环改善作用。与钙拮抗剂不同，它允许口服给药以抑制各种激动剂引起的血管收缩，并可用作冠状动脉、脑部、肾脏和外周动脉循环疾病的预防和治疗的强效长效药物，作为治疗高血压、心绞痛、肾脏和外周循环障碍的治疗剂，脑血管痉挛抑制剂等。此外，本发明的化合物还可用作哮喘的治疗剂。
• Antitumor effect potentiators
  申请人：——

  公开号：US20030165576A1

  公开（公告）日：2003-09-04

  When used concurrently with an antitumor agent, a compound having a Rho kinase inhibitory activity, such as (R)-(+)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide, reinforces an antitumor effect of the antitumor agent and is useful as an antitumor effect potentiator. Particularly, a compound having a Rho kinase inhibitory activity used with an antitumor agent in combination can reduce the dose of the antitumor agent, which in turn affords provision of a sufficient effect and/or reduction of side effects.

  当与抗肿瘤药物同时使用时，具有Rho激酶抑制活性的化合物，如(R)-(+)-N-(4-吡啶基)-4-(1-氨乙基)苯甲酰胺，可以增强抗肿瘤药物的抗肿瘤效果，并且可用作抗肿瘤效应增强剂。特别是，与抗肿瘤药物联合使用具有Rho激酶抑制活性的化合物可以降低抗肿瘤药物的剂量，从而提供足够的疗效和/或减少副作用。
• ANTITUMOR EFFECT POTENTIATORS
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1295607A1

  公开（公告）日：2003-03-26

  When used concurrently with an antitumor agent, a compound having a Rho kinase inhibitory activity, such as (R)-(+)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide, reinforces an antitumor effect of the antitumor agent and is useful as an antitumor effect potentiator. Particularly, a compound having a Rho kinase inhibitory activity used with an antitumor agent in combination can reduce the dose of the antitumor agent, which in turn affords provision of a sufficient effect and/or reduction of side effects.

  当与抗肿瘤药物同时使用时，具有 Rho 激酶抑制活性的化合物，如 (R)-(+)-N-(4-吡啶基)-4-(1-氨基乙基)苯甲酰胺，可增强抗肿瘤药物的抗肿瘤效果，并可用作抗肿瘤效果增效剂。 特别是，具有 Rho 激酶抑制活性的化合物与抗肿瘤药联合使用，可以减少抗肿瘤药的剂量，从而提供足够的效果和/或减少副作用。
• PAIN REMEDY CONTAINING ROCK INHIBITOR
  申请人：Astellas Pharma Inc.

  公开号：EP1854484A1

  公开（公告）日：2007-11-14

  Since a ROCK inhibitor exerts a potent analgesic effect by a single dose after the onset of a cartilage-related disease such as osteoarthritis, and can regenerate or suppress destruction of cartilage tissue and alleviate pain associated with cartilage diseases by multiple doses, administration of an therapeutically effective amount of the ROCK inhibitor to a patient with cartilage-related disease such as osteoarthritis or rheumatoid arthritis can treat the patient with cartilage-related disease and the ROCK inhibitor is thus useful.

  由于 ROCK 抑制剂在软骨相关疾病（如骨关节炎）发病后单次给药可发挥强效镇痛作用，多次给药可再生或抑制软骨组织的破坏，减轻与软骨疾病相关的疼痛，因此，对软骨相关疾病（如骨关节炎或类风湿性关节炎）患者施用治疗有效量的 ROCK 抑制剂可治疗软骨相关疾病患者，因此 ROCK 抑制剂是有用的。