5-Fluoro-5,6-dihydrouridine | 88291-54-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-Fluoro-5,6-dihydrouridine
• 英文别名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,3-diazinane-2,4-dione
• CAS: 88291-54-7
• 化学式: C₉H₁₃FN₂O₆
• 分子量: 264.21
• InChiKey: GSMVBLWSOUYVDG-NLQUXFCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU SARS-COV 2
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2021225767A1

  公开（公告）日：2021-11-11

  Disclosed herein are methods that are useful for treating a subject who has a pathogenic infection, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); reducing the likelihood of the subject from being infected by a pathogen; and for reducing the transmission of a pathogen from a subject to others. The methods utilize a compound disclosed in Table 1 or Table 4 herein, optionally in combination with an additional agent such as an anti-infective agent.