2,6-Dibromo-4-(4-hydroxy-butyl)-phenol | 748152-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-Dibromo-4-(4-hydroxy-butyl)-phenol
• 英文别名: 2,6-Dibromo-4-(4-hydroxybutyl)phenol
• CAS: 748152-11-6
• 化学式: C₁₀H₁₂Br₂O₂
• 分子量: 324.012
• InChiKey: KDQZZMJDVPSNOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-Dibromo-4-(4-hydroxy-butyl)-phenol 在 三氟化硼乙醚 、 四丁基高氯酸铵 作用下， 以 硝基甲烷 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 6,8-dibromo-2H,3H,4H,5H-benzo[f]oxepin-7-ol
  参考文献：
  名称：

  Plant-growth inhibitory activity of heliannuol derivatives

  摘要：

  In addition to (+)-, (-)- and (+/-)-heliannuol E, growth-inhibitory activities of five synthetic chromans and four tetrahydrobenzo[b]oxepins were examined against oat and cress. All heliannuol E isomers exhibited similar biological activities against cress, whereas when tested against oat roots, the unnatural optical isomer (+) showed no inhibitory activity. Four brominated chromans and two tetrahydrobenzo[b]oxepin derivatives also showed apparent inhibition against both cress and oat. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2004.03.035
• 作为产物：
  描述：

  4-(4-羟基苯基)-1-丁醇 在 溴 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 48.0h， 以53%的产率得到2-Bromo-4-(4-hydroxy-butyl)-phenol
  参考文献：
  名称：

  Plant-growth inhibitory activity of heliannuol derivatives

  摘要：

  In addition to (+)-, (-)- and (+/-)-heliannuol E, growth-inhibitory activities of five synthetic chromans and four tetrahydrobenzo[b]oxepins were examined against oat and cress. All heliannuol E isomers exhibited similar biological activities against cress, whereas when tested against oat roots, the unnatural optical isomer (+) showed no inhibitory activity. Four brominated chromans and two tetrahydrobenzo[b]oxepin derivatives also showed apparent inhibition against both cress and oat. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2004.03.035