1-[2-(benzo[1,3]dioxol-4-yl)-2-oxo-ethyl]-3-methyl-7-(2-butyn-1-yl)-8-[(S)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine | 668273-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-[2-(benzo[1,3]dioxol-4-yl)-2-oxo-ethyl]-3-methyl-7-(2-butyn-1-yl)-8-[(S)-3-(tert-butoxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine
• 英文别名: tert-butyl N-[(3S)-1-[1-[2-(1,3-benzodioxol-4-yl)-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate
• CAS: 668273-73-2
• 化学式: C₂₉H₃₄N₆O₇
• 分子量: 578.625
• InChiKey: PQMMRCVKDSTGNG-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  136
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：Himmelsbach Frank

  公开号：US20080255159A1

  公开（公告）日：2008-10-16

  The present invention relates to substituted xanthines of general formula wherein R 1 to R 3 are defined as in claims 1 to 16 , the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

  本发明涉及一般式的取代黄嘌呤，其中R1至R3的定义如权利要求1至16所述，其互变异构体、立体异构体、混合物、前药和盐具有有价值的药理特性，特别是对酶二肽基肽酶-IV（DPP-IV）的抑制作用。
• 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
  申请人：HIMMELSBACH Frank

  公开号：US20120208831A1

  公开（公告）日：2012-08-16

  The present invention relates to substituted xanthines of general formula wherein R 1 to R 3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

  本发明涉及一种一般式为R1至R3如定义所述的取代黄嘌呤，其互变异构体、立体异构体、混合物、前药和盐具有有价值的药理学性质，特别是对酶二肽基肽酶-IV（DPP-IV）的抑制作用。
• Methods for characterizing polymorphisms
  申请人：——

  公开号：US20020018999A1

  公开（公告）日：2002-02-14

  Methods are described for analyzing at least one polymorphic site in a biological sample containing at least one single-stranded template, including the steps of: combining the biological sample with a primer specific for each polymorphic site in each template and a primer extension preparation, to form an assay mixture; wherein the preparation includes: chain terminating nucleotides forming a first nucleotide class, chain elongating nucleotides forming a second nucleotide class such that the second nucleotide class does not include a nitrogenous base present in the first nucleotide class, and a template-dependent nucleic acid polymerase; incubating the mixture for a time and at a temperature sufficient to extend each primer by addition of at least one nucleotide; and determining the size of each extended primer. Kits suitable for practising the invention are also provided.

  描述了分析含有至少一个单链模板的生物样品中至少一个多态位点的方法，包括以下步骤：将生物样品与每个模板中每个多态位点的特异性引物和引物延伸制备物结合，形成检测混合物；其中制备物包括形成第一类核苷酸的链终止核苷酸、形成第二类核苷酸的链延长核苷酸（第二类核苷酸不包括第一类核苷酸中的含氮碱基）和依赖于模板的核酸聚合酶；将混合物在足以通过添加至少一种核苷酸延伸每种引物的时间和温度下孵育；以及确定每种延伸引物的大小。还提供了适用于实施本发明的试剂盒。
• US7407955B2
  申请人：——

  公开号：US7407955B2

  公开（公告）日：2008-08-05
• US8119648B2
  申请人：——

  公开号：US8119648B2

  公开（公告）日：2012-02-21