Acetamide, 2-(methylamino)-N-(3-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperidinyl)propyl)- | 1186135-88-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: Acetamide, 2-(methylamino)-N-(3-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperidinyl)propyl)-
• 英文别名: 2-(methylamino)-N-[3-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperidin-1-yl]propyl]acetamide
• CAS: 1186135-88-5
• 化学式: C₂₇H₃₅F₃N₄OS
• 分子量: 520.7
• InChiKey: MCPFFPSNFOISQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Novel Composition for Treatment of Diseases Related to Activated Lymphocytes
  申请人：Roth Stephen

  公开号：US20090275557A1

  公开（公告）日：2009-11-05

  The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.

  本发明涉及抑制活化淋巴细胞，包括T细胞和B细胞的增殖和诱导凋亡。该发明还提供了用于抑制活化淋巴细胞的增殖和诱导凋亡的组合物和方法，以及通过给予5-HT受体拮抗剂治疗与活化淋巴细胞相关的疾病的方法。
• Novel Compositions and Methods for Binding and Inhibiting 5-HT4 Receptor
  申请人：Roth Stephen

  公开号：US20100035858A1

  公开（公告）日：2010-02-11

  The present invention relates to compositions that bind to 5-HT4 receptors and inhibit proliferation of activated lymphocytes. The invention also provides methods for inhibiting proliferation and inducing cell death in activated immune cells, as well methods for treating diseases associated with activated immune cells by administering 5-HT4 receptor ligands.
• Phenothiazine Derivatives for Treatment of Asthma
  申请人：Roth Stephen

  公开号：US20100130457A1

  公开（公告）日：2010-05-27

  The present invention relates to decreasing inflammation and airway obstruction in asthma. The invention also provides compositions and methods of reducing allergic reactions associated with asthma.
• [EN] BINDING AND INHIBITING 5-HT4 RECEPTOR<br/>[FR] RÉCEPTEUR 5-HT4 DE LIAISON ET D'INHIBITION
  申请人：IMMUNE CONTROL INC

  公开号：WO2010009332A1

  公开（公告）日：2010-01-21

  The present invention relates to compositions that bind to 5-HT4 receptors and inhibit proliferation of activated lymphocytes. The invention also provides methods for inhibiting proliferation and inducing cell death in activated immune cells, as well methods for treating diseases associated with activated immune cells by administering 5-HT4 receptor ligands.
• [EN] PHENOTHIAZINE DERIVATIVES FOR TREATMENT OF ASTHMA<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE POUR LE TRAITEMENT DE L'ASTHME
  申请人：IMMUNE CONTROL INC

  公开号：WO2010056979A1

  公开（公告）日：2010-05-20

  The present invention relates to decreasing inflammation and airway obstruction in asthma. The invention also provides compositions and methods of reducing allergic reactions associated with asthma.